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Titolo:
Can a coated Dacron vascular graft maintain a heparin-induced thrombocytopenia type II?
Autore:
Burger, T; Tautenhahn, J; Bock, M; Fahlke, J; Halloul, Z; Lippert, H;
Indirizzi:
Otto Von Guericke Univ, Fak Med, Klin Allgemein Viszeral & Gefasschirurg, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Univ Wurzburg, Dept Transfus Med & Immunohematol, Wurzburg, Germany Univ Wurzburg Wurzburg Germany s Med & Immunohematol, Wurzburg, Germany
Titolo Testata:
LANGENBECKS ARCHIVES OF SURGERY
fascicolo: 4, volume: 386, anno: 2001,
pagine: 267 - 271
SICI:
1435-2443(200107)386:4<267:CACDVG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT HEPARIN; THROMBOSIS;
Keywords:
heparin-induced thrombocytopenia; unusual course; coated Dacron; vascular surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Burger, T Otto Von Guericke Univ, Fak Med, Klin Allgemein Viszeral & Gefasschirurg, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
T. Burger et al., "Can a coated Dacron vascular graft maintain a heparin-induced thrombocytopenia type II?", LANG ARCH S, 386(4), 2001, pp. 267-271

Abstract

In the course of reconstruction of peripheral arterial occlusion processes, two gelatin-coated Dacron grafts and one collagen-coated Dacron patch were implanted in a 52-year-old male patient. Eight days following low-dose heparinization (5 days prior to surgery, 3 days postoperatively) with unfractionated heparin, with no clinical symptoms present, a dramatic isolated thrombocyte depression occurred, from 212 Gpt/1 prior to surgery to 14 Gpt/1 on postoperative day 3. Laboratory tests verified an HIT type II [heparin-induced platelet aggregation assay (HIPAA) and ELISA]. Despite immediate discontinuation of heparin and commencement of an anticoagulant therapy with Revasc and Refludam, an 8-week thrombocyte depression occurred which was eliminated only temporarily by administration of gammaglobulin. The specific antibody tests turned out positive for more than 5 months. Having ruled out other causes of thrombocytopenia, we assume that the case presented was either due to an interaction not elucidated to date or triggered by the grafts (gelatin/collagen/Dacron). The manufacturers of the grafts have disputed a heparinoid action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 01:43:27