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Titolo:
In vitro antibody response to the tetrapeptide repeats of Plasmodium falciparum circumsporozoite protein by splenocytes from mice infected with P-yoelii yoelii
Autore:
Kobayashi, F; Tsuji, M; Weidanz, WP;
Indirizzi:
Kyorin Univ, Sch Med, Dept Infect Dis, Div Trop Dis & Parasitol, Tokyo 1818611, Japan Kyorin Univ Tokyo Japan 1818611 op Dis & Parasitol, Tokyo 1818611, Japan Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 biol & Immunol, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 7, volume: 63, anno: 2001,
pagine: 743 - 749
SICI:
0916-7250(200107)63:7<743:IVARTT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; T-CELLS; B-CELLS; MALARIA; INTERLEUKIN-10; LYMPHOCYTES; EXPRESSION; IL-10;
Keywords:
CSP; immunosuppression; malaria; NANP; Plasmodium yoelii;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, F Kyorin Univ, Sch Med, Dept Infect Dis, Div Trop Dis & Parasitol, Tokyo 1818611, Japan Kyorin Univ Tokyo Japan 1818611 sitol, Tokyo 1818611, Japan
Citazione:
F. Kobayashi et al., "In vitro antibody response to the tetrapeptide repeats of Plasmodium falciparum circumsporozoite protein by splenocytes from mice infected with P-yoelii yoelii", J VET MED S, 63(7), 2001, pp. 743-749

Abstract

The antibody response to the recombinant protein, R32tet32, which contained the repetitive sequence (NANP)(n) of Plasmodium falciparum CSP was determined in C57BL/6 mice during the course of nonlethal infection with Plasmodium yoelii 17X. Marked suppression of the IgG antibody response to R32tet32 occurred when mice were immunized at peak parasitemia (on day 16). In vitroantibody responses of spleen cells from acutely infected mice to R32tet32 were similarly suppressed. Stimulation of normal spleen cells cultured for 5 days with 100 ng/ml of R32tet32 gave an optimal IgG antibody response, but spleen cells from infected mice obtained at peak parasitemia failed to respond to a broad range of antigen concentrations. Cocultivation studies employing enriched lymphocyte populations from infected and uninfected C57BL/6mice indicated that both T and B cells from infected mice were defective in their response to R32tet32. The response to the repetitive region was restored by the addition of recombinant mouse interleukin-2 (IL-2) at a dose of 50 U/ml to cultures of spleen cells from infected mice.

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Documento generato il 13/07/20 alle ore 17:26:12