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Titolo:
Metabolism of the styrene metabolite 4-vinylphenol by rat and mouse liver and lung
Autore:
Carlson, GP; Rivera, AAP; Mantick, NA;
Indirizzi:
Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Hlth Sci, W Lafayette, IN 47907 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 7, volume: 63, anno: 2001,
pagine: 541 - 551
SICI:
1528-7394(200108)63:7<541:MOTSM4>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROSOMAL CYTOCHROME-P-450; INHALATION TOXICITY; B6C3F1 MICE; CD-1 MICE; HEPATOTOXICITY; INHIBITORS; INDUCTION; PYRIDINE; SUSCEPTIBILITY; PNEUMOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Carlson, GP Purdue Univ, Sch Hlth Sci, 1338 Civil Engn Bldg, W Lafayette, IN 47907 USA Purdue Univ 1338 Civil Engn Bldg W Lafayette IN USA 47907 USA
Citazione:
G.P. Carlson et al., "Metabolism of the styrene metabolite 4-vinylphenol by rat and mouse liver and lung", J TOX E H A, 63(7), 2001, pp. 541-551

Abstract

Styrene is a widely used chemical in the reinforced plastics industry and in polystyrene production. Its primary metabolic pathway to styrene oxide and then to styrene glycol, which is further metabolized to mandelic acid and phenylglyoxylic acid, has been well studied. However, a few studies have reported finding a minor metabolite, 4-vinylphenol ( 4-VP), in rat and human urine. The present studies sought to determine if the formation and metabolism of 4-VP in rat and mouse liver and lung preparations could be measured. When styrene was incubated with hepatic and pulmonary microsomal preparations, 4-VP formation could not be measured in these preparations. However,considerable 4-VP metabolizing activity, as determined by the loss of 4-VP, was observed in both mouse and rat liver and lung microsomal preparations. 4-Vinylphenol metabolizing activity in mouse liver microsomes was three times greater than that in rat liver microsomes, and activity in mouse lung microsomes was eight times greater than that in rat lung microsomes. This activity was completely absent in the absence of NADPH. Studies with cytochrome P-450 inhibitors indicated the involvement of CYP2E1 and CYP2F2. Induction of CYP2E1 by pyridine resulted in an increase in 4-VP metabolism by mouse hepatic microsomes but not by pulmonary microsomes. The metabolite(s) formed as a result of this oxidative pathway remain to be identified. In additional studies, glutathione conjugation appeared to be involved in 4-VP metabolism with the highest activity being in mouse lung, with or without the addition of NADPH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:00:32