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Titolo:
Mortality in mice infected with an amyocarditic coxsackievirus and given asubacute dose of mercuric chloride
Autore:
South, PK; Morris, VC; Levander, OA; Smith, AD;
Indirizzi:
USDA ARS, Beltsville Human Nutr Res Ctr, Nutr Requirements & Funct Lab, Beltsville, MD 20705 USA USDA ARS Beltsville MD USA 20705 ts & Funct Lab, Beltsville, MD 20705 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 7, volume: 63, anno: 2001,
pagine: 511 - 523
SICI:
1528-7394(200108)63:7<511:MIMIWA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMPLEX VIRUS TYPE-2; THIOREDOXIN REDUCTASE; VITAMIN-E; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; INDUCED MYOCARDITIS; METHYL MERCURY; B3 MYOCARDITIS; HEAVY-METALS; METHYLMERCURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, AD USDA ARS, Beltsville Human Nutr Res Ctr, Nutr Requirements & Funct Lab, Bldg 307,Rm 216,BARC E, Beltsville, MD 20705 USA USDA ARS Bldg 307,Rm 216,BARC E Beltsville MD USA 20705 0705 USA
Citazione:
P.K. South et al., "Mortality in mice infected with an amyocarditic coxsackievirus and given asubacute dose of mercuric chloride", J TOX E H A, 63(7), 2001, pp. 511-523

Abstract

An amyocarditic strain of coxsackievirus B3 (CVB3/0) induces heart damage when inoculated into selenium (Se)-deficient mice. Mercury (Hg), an Se antagonist, is known to aggravate viral infections. The experiments reported here assessed the effect of prior Hg treatment in mice subsequently inoculated with an amyocarditic strain of coxsackievirus. A pilot study showed that under our conditions the maximum tolerated dose of HgCl2 in uninfected micewas 6 mg HgCl2/kg body weight. In the main study, doses of 0, 3 or 6 mg HgCl2/kg body weight were administered intraperitoneally (ip) to 7-wk-old male mice fed a standard chow diet. Two hours later, half the mice were inoculated ip with CVB3/0. Ten days postinoculation, no mortality was observed inmice given only virus. In mice not given virus, 10% injected with 6 mg HgCl2/kg body weight died. On the other hand, 64% of the mice given both virusand 6 mg HgCl2/kg body weight died. Fifteen percent of the hearts from virus-infected mice given 3 mg HgCl2/kg body weight and 33% of the hearts fromvirus-infected mice given 6 mg HgCl2/kg body weight exhibited a higher incidence of lesions than hearts from mice-given virus alone. Moreover, viral heart titers were elevated in infected mice injected with 6 mg HgCl2/kg body weight compared to infected mice receiving no Hg. Thus, an amyocarditic coxsackievirus given to mice after a nonlethal subacute dose of Hg results in mortality, increased incidence of heart lesions, and elevated viral hearttiters. These results demonstrate the important role of toxic elements in determining the severity of viral infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:26:55