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Titolo:
Failure of urinary trans,trans-muconic acid as a biomarker for indoor environmental benzene exposure at PPB levels
Autore:
Sanguinetti, G; Accorsi, A; Barbieri, A; Raffi, GB; Violante, FS;
Indirizzi:
St Orsola Malpighi Hosp, Occupat Hlth Unit, I-40138 Bologna, Italy St Orsola Malpighi Hosp Bologna Italy I-40138 it, I-40138 Bologna, Italy Univ Bologna, Occupat Safety Hyg & Hlth Serv, Bologna, Italy Univ BolognaBologna Italy cupat Safety Hyg & Hlth Serv, Bologna, Italy Univ Bologna, Chair Occupat Med, Bologna, Italy Univ Bologna Bologna Italy v Bologna, Chair Occupat Med, Bologna, Italy
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 8, volume: 63, anno: 2001,
pagine: 599 - 604
SICI:
1528-7394(200108)63:8<599:FOUTAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCONIC ACID; HEALTH; METABOLITE; INDICATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sanguinetti, G St Orsola Malpighi Hosp, Occupat Hlth Unit, Via Palagi 9, I-40138 Bologna,Italy St Orsola Malpighi Hosp Via Palagi 9 Bologna Italy I-40138
Citazione:
G. Sanguinetti et al., "Failure of urinary trans,trans-muconic acid as a biomarker for indoor environmental benzene exposure at PPB levels", J TOX E H A, 63(8), 2001, pp. 599-604

Abstract

Benzene is a widespread pollutant whose main source in the environment is automotive emission. There is increasing interest in the exposure of the population to this pollutant as benzene is present also in the indoor environment due to cigarette smoke, drinking water, and food. The aim of this study was to evaluate, in an adult nonsmoking population not occupationally exposed to benzene, whether it is possible to detect differences in the urinary concentration of trans, trans-muconic acid (t,t-MA) between low and high environmental exposure to benzene. A study sample of 31 employees working in pharmacies in a large town in Italy with low environmental exposure to benzene (4.8 mug/m(3)) was compared to a high (8.1 mug/m(3)) benzene exposuregroup. Analysis of urinary t,t-MA was carried out by high-performance liquid chromatography ( HPLC; photodiode array detector); analysis of environmental benzene samples was by gas chromatography/ mass spectroscopy (GC-MS). The statistical analysis revealed no significant differences in urinary levels of t,t-MA of subjects with high (mean concentration: 157.9 mug/g(creatinine)) versus low exposure (mean concentration: 114.2 mug/g(creatinine)). Data show that it is difficult to correlate urinary t,t-MA with benzene exposure at parts per billion levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:20:36