Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokers
Autore:
Kim, HS; Lee, BM;
Indirizzi:
Sung Kyun Kwan Univ, Sch Pharm, Div Toxicol, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 , Suwon 440746, South Korea
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 8, volume: 63, anno: 2001,
pagine: 583 - 598
SICI:
1528-7394(200108)63:8<583:PEOASO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; D-ALPHA-TOCOPHEROL; VITAMIN-E; CIGARETTE-SMOKING; BETA-CAROTENE; FREE-RADICALS; OXIDATIVE STRESS; ASCORBIC-ACID; HUMANS; LDL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, BM Sung Kyun Kwan Univ, Sch Pharm, Div Toxicol, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 440746, South Korea
Citazione:
H.S. Kim e B.M. Lee, "Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokers", J TOX E H A, 63(8), 2001, pp. 583-598

Abstract

This study was designed to investigate the possible protective effects of antioxidants (vitamin E, beta -carotene, vitamin C, and red ginseng) on lipid peroxidation in smokers (greater than or equal to 20 cigarettes/day). Male student smokers were given antioxidant supplements for 4 wk. Smokers hadsignificantly higher plasma levels of total cholesterol, triacylglycerols,and malondialdehyde (MDA) than nonsmokers. No corresponding significant differences in lipid profiles were found between smokers and nonsmokers. Smokers had significantly lower baseline concentrations of plasma vitamin C, beta -carotene, and alpha -tocopherol. After antioxidant (200 IU vitamin E, 9mg beta -carotene, 500 mg vitamin C, or 1.8 g red ginseng) supplementationfor 4 wk, smokers had significantly higher concentrations of plasma antioxidants. Aft er 4 wk of antioxidant supplementation with beta -carotene, high-density lipoprotein (HDL) cholesterol concentrations in smokers were significantly increased. Overall, plasma MDA concentrations gradually decreasedafter antioxidant supplementation over the 4-wk period. Moreover, a significant reduction in plasma MDA concentrations was observed after vitamin E supplementation. The results of our study support the hypothesis that lipid peroxidation concentrations are inversely correlated with plasma antioxidant concentrations. Our data suggest that smokers have insufficient concentrations of antioxidant vitamins in plasma and that supplementation with antioxidants might protect smokers from oxidative damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:34:35