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Titolo:
Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients?
Autore:
Kymionis, GD; Dimitrakakis, CE; Konstadoulakis, MM; Arzimanoglou, I; Leandros, E; Chalkiadakis, G; Keramopoulos, A; Michalas, S;
Indirizzi:
Athens Med Sch, Hippokratio Hosp, Dept Propedeut Surg 1, Surg Res Lab, Athens, Greece Athens Med Sch Athens Greece edeut Surg 1, Surg Res Lab, Athens, Greece Athens Med Sch, Alexandra Hosp, Dept Obstet & Gynecol, Athens, Greece Athens Med Sch Athens Greece osp, Dept Obstet & Gynecol, Athens, Greece Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, New York, NY USA Cornell Univ New York NY USA ll, Dept Obstet & Gynecol, New York, NY USA Univ Hosp, Dept Gen Surg, Iraklion, Greece Univ Hosp Iraklion GreeceUniv Hosp, Dept Gen Surg, Iraklion, Greece
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 2, volume: 99, anno: 2001,
pagine: 161 - 168
SICI:
0022-4804(200108)99:2<161:CEOAGB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; PROGNOSTIC MARKERS; PROTEIN EXPRESSION; IN-VIVO; CARCINOMAS; P53; RESISTANCE; LYMPHOMA; PROLIFERATION; POSITIVITY;
Keywords:
breast cancer; node negative; apoptosis; bcl-2; bax; chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kymionis, GD Ag Sikelianou 4, Rethimnon 74100, Greece Ag Sikelianou 4 Rethimnon Greece 74100 himnon 74100, Greece
Citazione:
G.D. Kymionis et al., "Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients?", J SURG RES, 99(2), 2001, pp. 161-168

Abstract

Background. Although the status of the axillary lymph nodes is widely accepted to be associated with prognosis in breast cancer patients, there is a need for biomarkers to be analyzed as indicators of responsiveness to treatment. The objective of this study was to test the hypothesis that the expression of apoptosis genes, bcl-2 and bax, predicts survival and responsiveness to chemotherapy in node-negative breast cancer patients. Methods. One hundred thirty premenopausal women with primary breast carcinoma were studied for the expression of bcl-2 and bax genes. The relationship between the expression of bcl-2 and bax proteins and a series of markers of known prognostic value [such as tumor size, nuclear grade, receptors of the steroid hormones estrogen (ER) and progesterone (PgR)]. The associationof these proteins with survival and responsiveness to chemotherapy was also examined. Results. Sixty (46%) and sixty-four (49%) breast cancer cases were found positive for bcl-2 and bax, respectively, as indicated by immunohistochemistry. A statistically significant association was found between expression ofbcl-2 and tumor size (P = 0.001), low grade (grade I) (P = 0.002), positivity of ER (P = 0.001), positivity of PR (P = 0.03), and superior disease-free survival (DFS) (P = 0.04), and superior overall survival (OS) (P = 0.03). In contrast, no similar associations were observed for the bax gene. Overall, there was a trend toward an association between adjuvant chemotherapy and DFS (P = 0.08) and OS (P = 0.07). This trend became statistically significant when the patients were analyzed by individual gene expression. In bax-positive patients, chemotherapy improves 6-year DFS (P = 0.01) and OS (P = 0.03) while similar effects were not observed in the other subgroups of patients. Conclusion. Our results indicated that bcl-2 expression is associated witha number of favorable prognostic factors and better clinical outcome, while bax expression seems to have positive predictive value for responsivenessto chemotherapy in lymph node-negative breast cancer patients. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:45:08