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Titolo:
In vivo macrophage recruitment by murine intervertebral disc cells
Autore:
Rand, NS; Dawson, JM; Juliao, SF; Spengler, DM; Floman, Y;
Indirizzi:
Sulzer Spine Tech Inc, Spine Biomech Res, Minneapolis, MN 55439 USA SulzerSpine Tech Inc Minneapolis MN USA 55439 Minneapolis, MN 55439 USA
Titolo Testata:
JOURNAL OF SPINAL DISORDERS
fascicolo: 4, volume: 14, anno: 2001,
pagine: 339 - 342
SICI:
0895-0385(200108)14:4<339:IVMRBM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRODUCE MATRIX METALLOPROTEINASES; LOW-BACK-PAIN; NUCLEUS PULPOSUS; PROSTAGLANDIN E(2); BLOOD-VESSELS; NITRIC-OXIDE; NERVE ROOTS; INTERLEUKIN-6; TISSUE; PHOSPHOLIPASE-A2;
Keywords:
intervertebral disc; herniation; inflammation; macrophage; nucleus pulposus; annulus fibrosus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Dawson, JM Sulzer Spine Tech Inc, Spine Biomech Res, 7275 Bush Lake Rd, Minneapolis, MN 55439 USA Sulzer Spine Tech Inc 7275 Bush Lake Rd MinneapolisMN USA 55439
Citazione:
N.S. Rand et al., "In vivo macrophage recruitment by murine intervertebral disc cells", J SPINAL D, 14(4), 2001, pp. 339-342

Abstract

An in vivo murine experiment was conducted to measure the capacities of viable intervertebral disc cells to recruit inflammatory cells. The objectivewas to determine whether compounds secreted from viable cells induce inflammation or whether inflammation in disc herniation simply requires exposureto structural cell or matrix components. Three tissue preparations were inserted into the right lower peritoneal cavity of male mice: tissue with viable annulus fibrosus and nucleus pulposus cells, tissue with viable annulusfibrosus cells. or devitalized annulus fibrosus and nucleus pulposus tissue. Controls included sham-operated and nonoperated groups. Mice were killed1, 2, or 7 days after surgery. Macrophage recruitment occurred after exposure to viable disc tissue but not after exposure to devitalized disc components: recruitment increased over time, Viable disc cells play a role in theetiology of inflammation in disc herniation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:23:27