Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evaluation of the BBMEC model for screening the CNS permeability of drugs
Autore:
Otis, KW; Avery, ML; Broward-Partin, SM; Hansen, DK; Behlow, HW; Scott, DO; Thompson, TN;
Indirizzi:
Quintiles Inc, Kansas City, MO 64134 USA Quintiles Inc Kansas City MO USA64134 les Inc, Kansas City, MO 64134 USA Pfizer Inc, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340Pfizer Inc, Groton, CT 06340 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 1, volume: 45, anno: 2001,
pagine: 71 - 77
SICI:
1056-8719(200101/02)45:1<71:EOTBMF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN;
Keywords:
CNS permeability; in vitro model; blood brain barrier; transport study; P-glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, TN Quintiles Inc, POB 9708, Kansas City, MO 64134 USA Quintiles Inc POB 9708 Kansas City MO USA 64134 MO 64134 USA
Citazione:
K.W. Otis et al., "Evaluation of the BBMEC model for screening the CNS permeability of drugs", J PHARM TOX, 45(1), 2001, pp. 71-77

Abstract

Combinatorial synthesis and high-throughput pharmacology screening have greatly increased compound throughput in modem drug discovery programs. For CNS drugs, it is also important to determine permeability to the blood-brainbarrier. Yet, given the increased pace of discovery, it difficult to conduct this screen in a timely fashion. In this presentation, we describe several improvements to an existing CNS permeability screen, the bovine brain microvessel endothelial cell (BBMEC) model. By implementation of these incremental process improvements, we have achieved a robust, facile screen for determination of CNS permeability of multiple compounds. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:35:58