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Titolo:
Relationship between renal volume and increased albumin excretion rates inchildren and adolescents with type 1 diabetes mellitus
Autore:
Frazer, FL; Palmer, LJ; Clarey, A; Thonell, S; Byrne, GC;
Indirizzi:
Princess Margaret Hosp, Dept Radiol, Subiaco, WA 6008, Australia Princess Margaret Hosp Subiaco WA Australia 6008 iaco, WA 6008, Australia Univ Western Australia, Dept Paediat, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
fascicolo: 7, volume: 14, anno: 2001,
pagine: 875 - 881
SICI:
0334-018X(200107/08)14:7<875:RBRVAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION-RATE; INCREASED KIDNEY SIZE; INSULIN-TREATMENT; NEPHROPATHY; MICROALBUMINURIA; HYPERTENSION; HYPERTROPHY; PROGRESSION; DISEASE; IDDM;
Keywords:
borderline microalbuminuria; intermittent microalbuminuria; renal volume; albumin excretion rate; type 1 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
F.L. Frazer et al., "Relationship between renal volume and increased albumin excretion rates inchildren and adolescents with type 1 diabetes mellitus", J PED END M, 14(7), 2001, pp. 875-881

Abstract

Objective: To compare renal volume in a group of prepubertal and pubertal children with type 1 diabetes mellitus (DM) and either borderline microalbuminuria (BM) or intermittent microalbuminuria (IM) with a matched group of normoalbuminuric (NA) controls with DM. Research design and methods: Twenty-one patients with BM or IM were matched for age, gender and duration of DM with an NA control group. Total renal volume (RV), measured by ultrasound, was corrected for body surface area. Long-term diabetes control was assessed by glycosylated haemoglobin levels. Results: There were no significant differences in age, duration of DM or glycosylated haemoglobin levels between the groups. Those with BM or IM had significantly increased total renal volume (303 +/- 8.4 ml/1.73m(2)) compared to those with NA (276.3 +/- 10 ml/1.73m(2)) (T-40=2.04, P=0.05). Multivariate modelling suggested that this association was independent of potential confounding covariates. While not formally significant (chi (2)(1)=2.53, P=0.12), the frequency of nephromegaly (RV > 300 ml/1.73m(2)) was doubled in children with BM or IM (47.6%) compared to controls (23.8%). Nephromegalywas not found in prepubertal patients. Conclusions: This study suggests that nephromegaly is more common in patients with borderline increases in urinary albumin excretion rates (AER) thanthose with normoalbuminuria. Prospective follow-up of those with increasedrenal volume is needed to determine whether nephromegaly is an early marker of incipient nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:26:18