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Titolo:
[1-C-11]Acetate as a quantitative perfusion tracer in myocardial PET
Autore:
van den Hoff, J; Burchert, W; Borner, AR; Fricke, H; Kuhnel, G; Meyer, GJ; Otto, D; Weckesser, E; Wolpers, HG; Knapp, WH;
Indirizzi:
Hannover Med Sch, Klin Nukl Med, Dept Nucl Med, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 Med, D-30625 Hannover, Germany Hannover Med Sch, Dept Cardiol, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 iol, D-30625 Hannover, Germany Ruhr Univ Bochum, Heart Ctr Bad Oeynhausen, Dept Nucl Med, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 Nucl Med, D-4630 Bochum, Germany Univ Dresden, Dept Nucl Med, Dresden, Germany Univ Dresden Dresden Germany v Dresden, Dept Nucl Med, Dresden, Germany
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 8, volume: 42, anno: 2001,
pagine: 1174 - 1182
SICI:
0161-5505(200108)42:8<1174:[AAQPT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; REGIONAL BLOOD-FLOW; OXIDATIVE-METABOLISM; C-11 ACETATE; OXYGEN-CONSUMPTION; N-13 AMMONIA; NONINVASIVE ASSESSMENT; CANINE MYOCARDIUM; CARBON-11-ACETATE; QUANTIFICATION;
Keywords:
myocardial perfusion; acetate; extraction fraction; ammonia; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: van den Hoff, J Hannover Med Sch, Klin Nukl Med, Dept Nucl Med, Carl Neuberg Str 1, D-30625 Hannover, Germany Hannover Med Sch Carl Neuberg Str 1 Hannover Germany D-30625
Citazione:
J. van den Hoff et al., "[1-C-11]Acetate as a quantitative perfusion tracer in myocardial PET", J NUCL MED, 42(8), 2001, pp. 1174-1182

Abstract

Our objective was to investigate the properties of [1-C-11]acetate as a quantitative perfusion tracer for myocardial PET studies. Methods: We determined the flow dependence of the effective acetate extraction by a comparisonwith [N-13]ammonia in 24 patients at rest (n = 8) and under pharmacologic vasodilation (n = 16). Furthermore, we compared the statistical quality of the perfusion values derived with both tracers. Quantification was based onan irreversible 2-compartment model for [N-13]ammonia and a reversible 1-compartment model for [1-C-11]acetate. Area-conserving polar maps were used to determine the correlation between the unidirectional uptake parameters of both tracers on a pixel-by-pixel basis for the whole left ventricular myocardium. Results: A fit of a generalized Renkin-Crone formula to the data yielded the unidirectional acetate extraction fraction E(f) = 1 - 0.64e(-1.20/f). An extraction correction based on this formula led to good quantitative agreement of perfusion values derived with [N-13]ammonia and [1-C-11]acetate over the whole observed flow range (average difference of flow values,3%; correlation coefficient, 0.96). This agreement proved the applicability of acetate as a quantitative perfusion tracer even under stress conditions. An analysis of the statistical properties of the parameter estimates showed, moreover, that statistical errors were reduced by a factor of nearly 2in comparison with ammonia. Conclusion: [1-C-11]acetate allows accurate quantification of myocardial perfusion with PET at rest as well as under stress conditions. The use of acetate leads to distinctly improved statistical accuracy for the perfusion estimates in comparison with ammonia. This accuracy facilitates the generation of reliable parametric polar maps, which areespecially useful for clinical application of myocardial perfusion quantification.

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Documento generato il 29/02/20 alle ore 15:06:02