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Titolo:
Regional myocardial mechanics: Integrative computational models of flow-function relations
Autore:
McCulloch, AD; Mazhari, R;
Indirizzi:
Univ Calif San Diego, Whitaker Inst Biomed Engn, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ioengn, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 506 - 519
SICI:
1071-3581(200107/08)8:4<506:RMMICM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE LEFT-VENTRICLE; ACUTELY ISCHEMIC MYOCARDIUM; STUNNED MYOCARDIUM; BLOOD-FLOW; CORONARY STENOSIS; BORDER ZONE; POSTISCHEMIC MYOCARDIUM; EPICARDIAL DEFORMATION; NONISCHEMIC MYOCARDIUM; CONTRACTILE FUNCTION;
Keywords:
myocardial mechanics; stress and strain; computational model; myocardial stunning; ischemic border zone; regional myocardial perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: McCulloch, AD Univ Calif San Diego, Whitaker Inst Biomed Engn, Dept Bioengn, 9500 GilmanDr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 SA
Citazione:
A.D. McCulloch e R. Mazhari, "Regional myocardial mechanics: Integrative computational models of flow-function relations", J NUCL CARD, 8(4), 2001, pp. 506-519

Abstract

Many cardiac disorders result in regionally altered myocardial mechanics. Although myocardial strain distributions can be measured experimentally andclinically, regional wall stresses must be computed from computational models. Combining these approaches can provide insight into the structural basis of regional dysfunction under conditions such as acute myocardial infarction and ischemia-reperfusion. Recently, 3-dimensional computational modelshave helped to elucidate the structural basis of the functional border zone adjacent to acutely ischemic myocardium. They have also shown that heterogeneous dysfunction in ischemic-reperfused stunned myocardium does not necessarily imply heterogeneous myofilament injury. Now that computational models are able to reproduce many complex features of the 3-dimensional patterns of regional myocardial deformation observed experimentally, we suggest possible roles for such integrative models in clinical diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:46:59