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Titolo:
Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT
Autore:
Hirai, T; Nohara, R; Ogoh, S; Chen, LG; Kataoka, A; Li, XH; Fujita, M; Matsumori, A; Taguchi, S; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 ovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ, Grad Sch Human & Environm Studies, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 m Studies, Sakyo Ku, Kyoto 6068397, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 472 - 481
SICI:
1071-3581(200107/08)8:4<472:SEOFAM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IODOPHENYL PENTADECANOIC ACID; POSITRON EMISSION TOMOGRAPHY; CANINE MYOCARDIUM; TRACER AUTORADIOGRAPHY; CORONARY-ARTERY; IODINE-123-BMIPP; BMIPP; KINETICS; TL-201; REPERFUSION;
Keywords:
pinhole single photon emission computed tomography; fatty acid metabolism; perfusion-metabolism mismatch; myocardial infarction; reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 Sakyo Ku, Kyoto 6068397, Japan
Citazione:
T. Hirai et al., "Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT", J NUCL CARD, 8(4), 2001, pp. 472-481

Abstract

Background. Iodine 123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) is mainly trapped in the myocardium as triglyceride, depending on the adenosine triphosphate level. Ten percent to 20% of it is metabolized through alpha -oxidation after beta -oxidation; however, the precise mechanism of the regulatory pathways of BMIPP is yet to be clarified. Methods and Results. A brief left coronary artery occlusion (10-30 minutes) was performed in 28 male Wistar-Kyoto rats. Dual single photon emission computed tomography images of BMIPP and thallium 201 were obtained 3 days and 24 days after the operation. The activities of 3-hydroxyacyl-coenzyme A dehydrogenase (HAD), citrate synthase (CS), and alpha -glycerol-phosphate dehydrogenase (GPD) were then measured in both ischemic and nonischemic regions. BMIPP and TI-201 chloride severity scores were also evaluated conventionally. CS and HAD levels were significantly lower in the ischemic region than in the nonischemic region in the chronic group (CS, 102.9 +/- 28.1 vs 138.7 +/- 33.7 mu mol/g/min, respectively, P = .0051; HAD, 54.7 +/- 20.1 vs 78.6 +/- 18.7 mu mol/g/min, respectively, P = .0031). There was no difference in GPD between the ischemic and nonischemic regions. The BMIPP severity score had closer inverse relations with HAD (acute, r = -0.82; chronic, r = -0.80) and CS (acute, r = -0.87; chronic, r = -0.81), but not with GPD, than did TI-201 chloride severity score. Conclusions. BMIPP imaging correlates well with the activities of HAD and CS, suggesting that a decrease in BMIPP uptake reflects deterioration of both fatty acid metabolism and citrate cycle and shows information other thanregional myocardial perfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:51:25