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Titolo:
Myocardial perfusion in patients with total occlusion of a single coronaryartery with and without collateral circulation
Autore:
He, ZX; Mahmarian, JJ; Verani, MS;
Indirizzi:
Baylor Coll Med, Cardiol Sect, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cardiol Sect, Houston, TX 77030 USA Fu Wai Hosp, Dept Nucl Med, Beijing, Peoples R China Fu Wai Hosp BeijingPeoples R China Nucl Med, Beijing, Peoples R China Methodist Hosp, Houston, TX 77030 USA Methodist Hosp Houston TX USA 77030Methodist Hosp, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 452 - 457
SICI:
1071-3581(200107/08)8:4<452:MPIPWT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR FUNCTION; EMISSION COMPUTED-TOMOGRAPHY; VIABLE MYOCARDIUM; DEPENDENT MYOCARDIUM; TL-201 SCINTIGRAPHY; SESTAMIBI UPTAKE; BLOOD-FLOW; DISEASE; INFARCTION; EXERCISE;
Keywords:
collateral circulation; defect count activity; single-vessel total coronary occlusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Verani, MS Baylor Coll Med, Cardiol Sect, 6550 Fannin SM-677, Houston, TX 77030 USA Baylor Coll Med 6550 Fannin SM-677 Houston TX USA 77030 030 USA
Citazione:
Z.X. He et al., "Myocardial perfusion in patients with total occlusion of a single coronaryartery with and without collateral circulation", J NUCL CARD, 8(4), 2001, pp. 452-457

Abstract

Background. Previous studies that investigated the effects of coronary collateral circulation on myocardial perfusion were compromised by inclusion of patients with multivessel coronary artery disease, incomplete occlusion, prior myocardial infarction, or a combination of these. In this study we ascertained the relationship between angiographic collateral circulation and myocardial perfusion only in patients with total occlusion of a single coronary artery, in the absence of myocardial infarction or significant stenosis in the other coronary arteries. Methods and Results. Seventy-one consecutive patients underwent stress myocardial single photon emission computed tomography within 90 days of angiography. Collateral circulation was present in 49 patients and absent in 22 patients. All but 2 patients had abnormal perfusion by single photon emission computed tomography imaging, with a mean defect size of 19% +/- 12%, and most (83%) had reversible perfusion defects. Defect count activities improved from stress to rest (or redistribution) (45% +/- 13% to 59% +/- 14%, P <.001). Abnormal myocardial perfusion occurred with similar frequency in patients with collateral circulation and in those without it. Total defect size was 19 % <plus/minus> 12% in patients with and 18 % +/- 11% in those without collateral circulation (P = not significant). The extent of reversibility and defect count activity during stress and rest were similar in patients with collateral circulation and in those without it. Conclusions. In patients with a single-vessel total coronary occlusion andwithout myocardial infarction, stress-induced myocardial ischemia is almost always present, irrespective of presence or absence of angiographic collaterals. These data lend support to the premise that collateral circulation is rather insufficient to prevent stress-induced ischemia, although it can preserve myocardial viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:30:51