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Titolo:
Long-term effect of simvastatin on the improvement of impaired myocardial flow reserve in patients with familial hypercholesterolemia without gender variance
Autore:
Yokoyama, I; Yonekura, K; Inoue, Y; Ohtomo, K; Nagai, R;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan Univ Tokyo Tokyo Japan Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo, Japan Univ Tokyo Tokyo Japan v Tokyo, Grad Sch Med, Dept Radiol, Tokyo, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 445 - 451
SICI:
1071-3581(200107/08)8:4<445:LEOSOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; CORONARY-ARTERY DISEASE; LIPID-LOWERING THERAPY; PERFUSION ABNORMALITIES; DIABETES-MELLITUS; N-13 AMMONIA; BLOOD-FLOW; CHOLESTEROL; ATHEROSCLEROSIS; DIPYRIDAMOLE;
Keywords:
cholesterol; simvastatin; myocardial flow reserve; positron emission tomography; nitrogen 13 ammonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, I 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan 7-3-1 Hongo,Bunkyo Ku Tokyo Japan 1138655 kyo 1138655, Japan
Citazione:
I. Yokoyama et al., "Long-term effect of simvastatin on the improvement of impaired myocardial flow reserve in patients with familial hypercholesterolemia without gender variance", J NUCL CARD, 8(4), 2001, pp. 445-451

Abstract

Background. Impaired myocardial flow reserve (MFR) in patients with familial hypercholesterolemia (FH) without evidence of ischemia has been reported. However, it has not been clarified whether diminished MFR in such male orfemale patients with FH can be reversed by simvastatin. Methods and Results. Sixteen patients with FH and 16 age-matched control subjects were studied. All patients were proved to have no evidence of exercise stress-induced myocardial ischemia. Baseline myocardial blood flow (MBF) and MBF during dipyridamole administration (MBF [DP]) were measured with positron emission tomography and nitrogen 13 ammonia; MFR was then calculated before and 9 to 15 months after therapy with sinivastatin (5-10 mg/day). Total cholesterol level was significantly higher in patients with FH (277 /- 49.0) than in control subjects (190 +/- 14.9) but was normalized after lipid-lowering therapy (205 +/- 40.3). Baseline MBF was comparable among FHpatients before (77.6 +/- 11.6 mL/min/100 g) and after therapy (74.5 +/- 9.62 mL/min/100 g) and control subjects (78.5 +/- 29.9 mL/min/100 g). However, MBF (DP) in FH patients before therapy (178 +/- 50.9 mL/min/100 g) was significantly lower than that in control subjects (282 +/- 148 mL/min/100 g)and was significantly improved after therapy (228 +/- 91.6 mL/min/100 g, P< .05). In fact, there was no statistically significant difference in the MBF (DP) value in FH patients after therapy compared with that in control subjects (P = .09). MFR significantly improved after therapy in patients with FH (3.33 <plus/minus> .19 vs 2.27 +/- 0.625, P < .01) and was then statistically comparable to that in control subjects (3.54 <plus/minus> 1.11). Improvement of MFR was observed whether MBF (DP) before therapy was greater than or less than 200 mL/min/100 g. MFR was improved in both male and femalepatients with FH. There was a significant relationship between percent change in plasma total cholesterol concentration and percent change in MFR before and after lipid-lowering therapy (r = -0.57, P < .05). Conclusions. Diminished MFR in patients with FH without evidence of ischemia can be reversed by moderate- to long-term sinivastatin therapy without gender variance.

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Documento generato il 18/01/20 alle ore 11:12:08