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Titolo:
Prediction of severe coronary artery disease and long-term outcome in patients undergoing vasodilator SPECT
Autore:
Ho, KT; Miller, TD; Christian, TF; Hodge, DO; Gibbons, RJ;
Indirizzi:
Mayo Clin, Dept Internal Med & Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin, Dept Biostat, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 n, Dept Biostat, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 438 - 444
SICI:
1071-3581(200107/08)8:4<438:POSCAD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ST-SEGMENT DEPRESSION; EMISSION COMPUTED-TOMOGRAPHY; INCREMENTAL PROGNOSTIC VALUE; MEDICALLY TREATED PATIENTS; ISCHEMIC-HEART-DISEASE; MYOCARDIAL-ISCHEMIA; NONINVASIVE IDENTIFICATION; HEMODYNAMIC DETERMINANTS; RISK STRATIFICATION; TL-201 SCINTIGRAPHY;
Keywords:
pharmacologic single photon emission computed tomography; left main coronary artery disease; 3-vessel coronary artery disease; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, TD Mayo Clin, Dept Internal Med & Cardiovasc Dis, East 16-B,200 1st St SW, Rochester, MN 55905 USA Mayo Clin East 16-B,200 1st St SW Rochester MN USA 55905 05 USA
Citazione:
K.T. Ho et al., "Prediction of severe coronary artery disease and long-term outcome in patients undergoing vasodilator SPECT", J NUCL CARD, 8(4), 2001, pp. 438-444

Abstract

Background. Vasodilator perfusion imaging has not been extensively evaluated for predicting severe coronary artery disease (CAD) or long-term prognosis. Methods and Results. The goals of this study were to develop a model to predict left main/3-vessel CAD in patients undergoing vasodilator thallium 201 imaging and coronary angiography (angiographic population) and to test the long-term prognostic value of this model in a separate cohort of patientswho were not referred for angiography (prognostic population). In the angiographic population (n = 653) the chi (2) value of the clinical model (containing the variables age, sex, and prior myocardial infarction) in the prediction of severe CAD was 32. The addition of 3 vasodilator TI-201 variables(magnitude of ST-segment depression, summed reversibility score, and increased lung uptake) increased the model chi (2) value to 114 (P < .001). Only9% of predicted low-risk patients versus 57% of predicted high-risk patients had severe CAD. In the prognostic population (n = 521) survival rates free of cardiac death or myocardial infarction at 7 years were 91%, 73%, and 51%, respectively, for patient groups predicted to be at low, intermediate,and high risk of severe CAD (P < .001). Conclusions. Clinical and vasodilator TI-201 variables can accurately predict the risk of severe CAD. Stress TI-201 variables add incremental information to clinical variables. The same model also predicts patient outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:55:06