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Titolo:
The inferior parietal lobule is the target of output from the superior colliculus, hippocampus, and cerebellum
Autore:
Clower, DM; West, RA; Lynch, JC; Strick, PL;
Indirizzi:
Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 urobiol, Pittsburgh, PA 15261 USA Vet Adm Med Ctr, Res Serv, Pittsburgh, PA 15261 USA Vet Adm Med Ctr Pittsburgh PA USA 15261 es Serv, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ol Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Cognit, Pittsburgh, PA 15261 USA SUNY Hlth Sci Ctr, Dept Physiol, Syracuse, NY 13210 USA SUNY Hlth Sci CtrSyracuse NY USA 13210 t Physiol, Syracuse, NY 13210 USA Vet Affairs Med Ctr, Cent New York Res Corp, Syracuse, NY 13210 USA Vet Affairs Med Ctr Syracuse NY USA 13210 es Corp, Syracuse, NY 13210 USA Univ Mississippi, Med Ctr, Dept Anat, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 r, Dept Anat, Jackson, MS 39216 USA Univ Mississippi, Med Ctr, Dept Ophthalmol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 t Ophthalmol, Jackson, MS 39216 USA Univ Mississippi, Med Ctr, Dept Neurol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Dept Neurol, Jackson, MS 39216 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 21, anno: 2001,
pagine: 6283 - 6291
SICI:
0270-6474(20010815)21:16<6283:TIPLIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL INTRAPARIETAL AREA; RECEPTIVE-FIELD ORGANIZATION; SACCADE-RELATED ACTIVITY; SPATIAL VIEW CELLS; FRONTAL EYE FIELD; RHESUS-MONKEY; MACAQUE MONKEY; CORTICOCORTICAL CONNECTIONS; TRANSNEURONAL TRANSPORT; PRIMATE HIPPOCAMPUS;
Keywords:
posterior parietal cortex; LIP; area 7a; area 7b; dentate nucleus; oculomotor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Strick, PL Univ Pittsburgh, Dept Neurobiol, W1640 Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15261 USA Univ Pittsburgh W1640 Biomed Sci Tower,200 Lothrop St Pittsburgh PA USA 15261
Citazione:
D.M. Clower et al., "The inferior parietal lobule is the target of output from the superior colliculus, hippocampus, and cerebellum", J NEUROSC, 21(16), 2001, pp. 6283-6291

Abstract

The inferior parietal lobule (IPL) is a functionally and anatomically heterogeneous region that is concerned with multiple aspects of sensory processing and sensorimotor integration. Although considerable information is available about the corticocortical connections to the IPL, much less is known about the origin and importance of subcortical inputs to this cortical region. To examine this issue, we used retrograde transneuronal transport of the McIntyre-B strain of herpes simplex virus type 1 (HSV1) to identify the second-order neurons in subcortical nuclei that project to the IPL. Four monkeys (Cebus apella) received injections of HSV1 into three different subregions of the IPL. Injections into a portion of the lateral intraparietal area labeled second-order neurons primarily in the superficial (visual) layersof the superior colliculus. Injections of HSV1 into a portion of area 7a labeled many second-order neurons in the CA1 region of the hippocampus. In contrast, virus injections within a portion of area 7b labeled second-order neurons in posterior regions of the dentate nucleus of the cerebellum. These observations have some important functional implications. The IPL is known to be involved in oculomotor and attentional mechanisms, the establishment of maps of extrapersonal space, and the adaptive recalibration of eye-hand coordination. Our findings suggest that these functions are subserved by distinct subcortical systems from the superior colliculus, hippocampus, andcerebellum. Furthermore, the finding that each system appears to target a separate subregion of the IPL provides an anatomical substrate for understanding the functional heterogeneity of the IPL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:31:30