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Titolo:
Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance
Autore:
Nikkhah, G; Falkenstein, G; Rosenthal, C;
Indirizzi:
Nordstadt Hosp, Neurosurg Clin, D-30167 Hannover, Germany Nordstadt Hosp Hannover Germany D-30167 Clin, D-30167 Hannover, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 21, anno: 2001,
pagine: 6252 - 6263
SICI:
0270-6474(20010815)21:16<6252:RPODNT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PARKINSON-MODEL; SKILLED FORELIMB USE; BILATERAL 6-OHDA LESIONS; NIGROSTRIATAL DOPAMINE; NIGRAL TRANSPLANTS; SUBSTANTIA-NIGRA; STRIATAL TRANSPLANTS; BEHAVIORAL RECOVERY; PAW PREFERENCE; STAIRCASE TEST;
Keywords:
Parkinson's disease; 6-hydroxydopamine; skilled forelimb use; stepping; sensorimotor behavior; nigrostriatal dopamine system; hemispheric lateralization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Nikkhah, G Nordstadt Hosp, Neurosurg Clin, Haltenhoffstr 41, D-30167 Hannover, Germany Nordstadt Hosp Haltenhoffstr 41 Hannover Germany D-30167 rmany
Citazione:
G. Nikkhah et al., "Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance", J NEUROSC, 21(16), 2001, pp. 6252-6263

Abstract

The ability of dopaminergic (DA) transplants to restore complex sensorimotor behaviors in experimental Parkinson's disease is dependent on graft survival and reinnervation and is likely to be further modified by complex functional graft-host interactions. Here, we examined the impact of hemisphericdominance and extensive testing regimes on the functional capabilities of DA transplants to restore skilled forelimb movements in rats with unilateral 6-hydroxydopamine lesions. Interestingly, a near complete recovery was observed in DA-grafted animals that did not exhibit a strong hemispheric lateralization for paw use before lesion and implantation surgery, whereas animals with a clear lateralization of paw use and grafted into the contralateral hemisphere exhibited only moderate recovery. Finally, animals grafted ipsilateral to the preferred paw were most resistant to functional improvements in skilled forelimb use. However, the influence of hemispheric dominanceon the degree of functional DA graft-induced restoration was specific for skilled forelimb use, whereas no such differences were observed in other tests for motor and sensory functions related to the DA system. Furthermore, functional recovery of DA-grafted animals in skilled forelimb use was significantly promoted by extensive behavioral testing regimes indicative of a "learning how to use" the transplant effect. These findings indicate the importance of the underlying functional architecture of complex sensorimotor behaviors, such as skilled forelimb use, andthe DA neurotransmitter system for the plasticity of DA transplants to promoting a more complete behavioral recovery in experimental, and potentially, also in clinical forms of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:28:10