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Titolo:
Remodeling of synaptic membranes after induction of long-term potentiation
Autore:
Toni, N; Buchs, PA; Nikonenko, I; Povilaitite, P; Parisi, L; Muller, D;
Indirizzi:
Ctr Med Univ Geneva, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva Geneva Switzerland 4 , CH-1211 Geneva 4, Switzerland
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 21, anno: 2001,
pagine: 6245 - 6251
SICI:
0270-6474(20010815)21:16<6245:ROSMAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEGMENTED POSTSYNAPTIC DENSITIES; CULTURED HIPPOCAMPAL-NEURONS; CENTRAL-NERVOUS-SYSTEM; ACTIN-BASED PLASTICITY; DENDRITIC SPINES; PERFORATED SYNAPSES; AXOSPINOUS SYNAPSES; RAT NEOCORTEX; 3-DIMENSIONAL STRUCTURE; RECEPTOR ACTIVATION;
Keywords:
morphology; postsynaptic density; coated vesicles; plasticity; hippocampus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, D Ctr Med Univ Geneva, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva Geneva Switzerland 4 Geneva 4, Switzerland
Citazione:
N. Toni et al., "Remodeling of synaptic membranes after induction of long-term potentiation", J NEUROSC, 21(16), 2001, pp. 6245-6251

Abstract

Several morphological changes of synapses have been reported to be associated with the induction of long-term potentiation (LTP) in the CA1 hippocampus, including an transient increase in the proportion of synapses with perforated postsynaptic densities (PSDs) and a later occurrence of multiple spine boutons (MSBs) in which the two spines arise from the same dendrite. To investigate the functional significance of these modifications, we analyzedsingle sections and reconstructed 134 synapses labeled via activity using a calcium precipitation approach. Analyses of labeled spine profiles showedchanges of the spine head area, PSD length, and proportion of spine profiles containing a coated vesicle that reflected variations in the relative proportion of different types of synapses. Three-dimensional reconstruction indicated that the increase of perforated spine profiles observed 30 min after LTP induction essentially resulted from synapses exhibiting segmented, completely partitioned PSDs. These synapses had spine head and PSD areas approximately three times larger than those of simple synapses. They containedcoated vesicles in a much higher proportion than that of any other type ofsynapse and exhibited large spinules associated with the PSD. Also the MSBs with two spines arising from the same dendrite that were observed 1-2 hr after LTP induction included a spine that was smaller and a PSD that was smaller than those of simple synapses. These results support the idea that LTP induction is associated with an enhanced recycling of synaptic membrane and that this process could underlie the formation of synapses with segmented PSDs and eventually result in the formation of a new, immature spine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:47:09