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Titolo:
Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking
Autore:
Lan, JY; Skeberdis, VA; Jover, T; Zheng, X; Bennett, MVL; Zukin, RS;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 16, volume: 21, anno: 2001,
pagine: 6058 - 6068
SICI:
0270-6474(20010815)21:16<6058:AOMGR1>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; LONG-TERM POTENTIATION; CEREBELLAR GRANULE CELLS; MGLUR1 MUTANT MICE; RAT HIPPOCAMPUS; XENOPUS OOCYTES; NEUROTRANSMITTER RELEASE; SIGNAL-TRANSDUCTION; OPEN PROBABILITY; NEURONS;
Keywords:
metabotropic glutamate receptors; NMDA receptors; receptor trafficking; channel gating; protein kinase C; (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylic acid; ACPD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Zukin, RS Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, 1300 Morris Pk Ave, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med 1300 Morris Pk Ave Bronx NY USA 10461
Citazione:
J.Y. Lan et al., "Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking", J NEUROSC, 21(16), 2001, pp. 6058-6068

Abstract

Regulation of neuronal NMDA receptors (NMDARs) by group I metabotropic glutamate receptors (mGluRs) is known to play a critical role in synaptic transmission. The molecular mechanisms underlying mGluR1-mediated potentiation of NMDARs are as yet unclear. The present study shows that in Xenopus oocytes expressing recombinant receptors, activation of mGluR1 potentiates NMDA channel activity by recruitment of new channels to the plasma membrane via regulated exocytosis. Activation of mGluR1 alpha induced (1) an increase inchannel number times channel open probability, with no change in mean opentime, unitary conductance, or reversal potential; (2) an increase in charge transfer in the presence of NMDA and the open channel blocker MK-801, indicating an increased number of functional NMDARs in the cell membrane; and (3) increased NR1 surface expression, as indicated by cell surface Western blots and immunofluorescence. Botulinum neurotoxin A or expression of a dominant negative mutant of synaptosomal associated protein of 25 kDa molelcular mass (SNAP-25) greatly reduced mGluR1 alpha -mediated potentiation, indicating that receptor trafficking occurs via a SNAP-25-mediated form of soluble N-ethylmaleimide sensitive fusion protein attachment protein receptor-dependent exocytosis. Because group I mGluRs are localized to the perisynaptic region in juxtaposition to synaptic NMDARs at glutamatergic synapses in the hippocampus, mGluR-mediated insertion of NMDARs may play a role in synaptic transmission and plasticity, including long-term potentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:13:00