Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Resonance of spike discharge modulation in neurons of the guinea pig medial vestibular nucleus
Autore:
Ris, L; Hachemaoui, M; Vibert, N; Godaux, E; Vidal, PP; Moore, LE;
Indirizzi:
Univ Paris 05, CNRS, Lab Neurobiol Reseaux Sensorimoteurs, ESA 7060, F-75270 Paris 06, France Univ Paris 05 Paris France 06 oteurs, ESA 7060, F-75270 Paris 06, France Univ Mons, Neurosci Lab, B-7000 Mons, Belgium Univ Mons Mons Belgium B-7000 v Mons, Neurosci Lab, B-7000 Mons, Belgium
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 2, volume: 86, anno: 2001,
pagine: 703 - 716
SICI:
0022-3077(200108)86:2<703:ROSDMI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRINSIC MEMBRANE-PROPERTIES; APPLIED GALVANIC CURRENTS; CANAL AFFERENT-FIBERS; LARVAL SPINAL NEURONS; SOMA VOLTAGE-CLAMP; BRAIN-STEM SLICES; SQUIRREL-MONKEY; IN-VITRO; NERVE AFFERENTS; ELECTROPHYSIOLOGICAL PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, LE Univ Paris 05, CNRS, Lab Neurobiol Reseaux Sensorimoteurs, ESA 7060, 45 Rue St Peres, F-75270 Paris 06, France Univ Paris 05 45 Rue St Peres Paris France 06 Paris 06, France
Citazione:
L. Ris et al., "Resonance of spike discharge modulation in neurons of the guinea pig medial vestibular nucleus", J NEUROPHYS, 86(2), 2001, pp. 703-716

Abstract

The modulation of action potential discharge rates is an important aspect of neuronal information processing. In these experiments, we have attemptedto determine how effectively spike discharge modulation reflects changes in the membrane potential in central vestibular neurons. We have measured how their spike discharge rate was modulated by various current inputs to obtain neuronal transfer functions. Differences in the modulation of spiking rates were observed between neurons with a single, prominent after hyperpolarization (AHP, type A neurons) and cells with more complex AHPs (type B neurons). The spike discharge modulation amplitudes increased with the frequency of the current stimulus, which was quantitatively described by a neuronal model that showed a resonance peak > 10 Hz. Modeling of the resonance peak required two putative potassium conductances whose properties had to be markedly dependent on the level of the membrane potential. At low frequencies (less than or equal to0.4 Hz), the gain or magnitude functions of type A and B discharge rates were similar relative to the current input. However, resting input resistances obtained from the ratio of the membrane potentialand current were lower in type B compared with type A cells, presumably due to a higher level of active potassium conductances at rest. The lower input resistance of type B neurons was compensated by a twofold greater sensitivity of their firing rate to changes in membrane potential, which suggeststhat synaptic inputs on their dendritic processes would be more efficacious. This increased sensitivity is also reflected in a greater ability of type B neurons to synchronize with low-amplitude sinusoidal current inputs, and in addition, their responses to steep slope ramp stimulation are enhancedover the more linear behavior of type A neurons. This behavior suggests that the type B MVNn are moderately tuned active filters that promote high-frequency responses and that type A neurons are like low-pass filters that are well suited for the resting tonic activity of the vestibular system. However, the more sensitive and phasic type B neurons contribute to both low- and high-frequency control as well as signal detection and would amplify thecontribution of both irregular and regular primary afferents at high frequencies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:58:39