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Titolo:
SOME PLASMA CONSTITUENTS CORRELATE WITH HUMAN CATARACT LOCATION AND NUCLEAR COLOR
Autore:
DONNELLY CA; SETH J; CLAYTON RM; PHILLIPS CI; CUTHBERT J;
Indirizzi:
UNIV UNIT,PRINCESS ALEXANDRA EYE PAVIL,CHALMERS ST EDINBURGH EH3 9HA MIDLOTHIAN SCOTLAND UNIV OXFORD,DEPT ZOOL,CTR EPIDEMIOL INFECT DIS OXFORD OX1 3PS ENGLAND ROYAL INFIRM EDINBURGH NHS TRUST,DEPT CLIN BIOCHEM EDINBURGH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,ICAPB DIV BIOL EDINBURGH EH8 9YL MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT SURG,OPHTHALMOL UNIT EDINBURGH EH8 9YL MIDLOTHIANSCOTLAND ROYAL INFIRM EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
Ophthalmic research
fascicolo: 4, volume: 29, anno: 1997,
pagine: 207 - 217
SICI:
0030-3747(1997)29:4<207:SPCCWH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAVER DAM EYE; POSTERIOR SUBCAPSULAR CATARACTS; MULTIPLE TEST PROCEDURES; CIGARETTE-SMOKING; LENS OPACITIES; RISK-FACTORS; ALCOHOL-USE; EPIDEMIOLOGY; POPULATION;
Keywords:
STEROIDS; PLASMA CONSTITUENTS; CATARACT; INCREASED TOTAL PROTEIN; DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Donnelly et al., "SOME PLASMA CONSTITUENTS CORRELATE WITH HUMAN CATARACT LOCATION AND NUCLEAR COLOR", Ophthalmic research, 29(4), 1997, pp. 207-217

Abstract

Aims: To look for differences in levels of various plasma constituents between pair-matched controls and patients who had cataracts classified by location and appearance of lens opacity and nuclear colour in order to identify systemic risk factors. Methods: One thousand patientswere taken from the cataract waiting list of a specialist eye hospital. For each patient, a matched control of the same sex and half-decadeof age but without cataract was taken from the patient-list of the family doctor of the patient; the control was the next alphabetically after the patient on the doctor's list. At an early morning visit to thehomes of both patients and controls, fasting, a team of nurses performed venepunctures and collected information for a questionnaire. Eye examinations were performed by a team of ophthalmologists. Results: Predominantly nuclear cataract was significantly associated with raised plasma alanine aminotransferase and bilirubin, posterior subcapsular cataract with increased calcium and urea, cuneiform with reduced potassium, mature/hypermature with raised potassium and reduced total carbon dioxide. The following were consistently significantly associated withall forms of cataract: diabetes and raised plasma glucose (not in non-diabetics), use of steroid medication, raised levels of cortisol (steroid users excluded), albumin, alkaline phosphatase, gamma-glutamyl transpeptidase, sodium and total protein and reduced levels of cholesterol and albumin/(total protein - albumin) ratio (an approximation for the albumin/globulin ratio). The multivariate analysis indicated that the most important non-specific cataractogenic effects were those of increased total protein, diabetes and use of steroid medication. Conclusion: This and other studies support, broadly, the conclusions that senile or age-related cataract is not merely caused by increasing age andalso that various morphological types have different risk factors. The mechanisms underlying the biochemical associations with different patterns of lens opacification and the identification of the ultimate risk factors remain to be elucidated.

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Documento generato il 22/09/20 alle ore 14:05:35