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Titolo:
ABCA1: the gatekeeper for eliminating excess tissue cholesterol
Autore:
Oram, JF; Lawn, RM;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA CV Therapeut Inc, Palo Alto, CA 94305 USA CV Therapeut Inc Palo Alto CA USA 94305 peut Inc, Palo Alto, CA 94305 USA
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 8, volume: 42, anno: 2001,
pagine: 1173 - 1179
SICI:
0022-2275(200108)42:8<1173:ATGFEE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATP-BINDING-CASSETTE; DENSITY-LIPOPROTEIN DEFICIENCY; APOLIPOPROTEIN-A-I; TANGIER-DISEASE PATIENTS; CELLULAR CHOLESTEROL; INTRACELLULAR CHOLESTEROL; ELECTRON-MICROSCOPY; MEDIATED REMOVAL; PLASMA-MEMBRANE; P-GLYCOPROTEIN;
Keywords:
HDL; reverse cholesterol transport; cellular cholesterol trafficking; cholesterol efflux; phospholipid efflux; cardiovascular disease; Tangier disease; LXR; ABCA1 gene regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Oram, JF Univ Washington, Dept Med, Box 356426,1959 NE Pacific Pl, Seattle, WA 98195 USA Univ Washington Box 356426,1959 NE Pacific Pl Seattle WA USA98195
Citazione:
J.F. Oram e R.M. Lawn, "ABCA1: the gatekeeper for eliminating excess tissue cholesterol", J LIPID RES, 42(8), 2001, pp. 1173-1179

Abstract

It is widely believed that HDL functions to transport cholesterol from peripheral cells to the liver by reverse cholesterol transport, a pathway thatmay protect against atherosclerosis by clearing excess cholesterol from arterial cells. A cellular ATP-binding cassette transporter (ABC) called ABCA1 mediates the first step of reverse cholesterol transport: the transfer ofcellular cholesterol and phospholipids to lipid-poor apolipoproteins. Mutations in ABCA1 cause Tangier disease (TD), a severe HDL deficiency syndromecharacterized by accumulation of cholesterol in tissue macrophages and prevalent atherosclerosis. Studies of TD heterozygotes revealed that ABCA1 activity is a major determinant of plasma HDL levels and susceptibility to CVD. Drugs that induce ABCA1 in mice increase clearance of cholesterol from tissues and inhibit intestinal absorption of dietary cholesterol. Multiple factors related to lipid metabolism and other processes modulate expression and tissue distribution of ABCA1. Therefore, as the primary gatekeeper for eliminating tissue cholesterol, ABCA1 has a major impact on cellular and whole body cholesterol metabolism and is likely to play an important role in protecting against cardiovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:50:01