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Titolo:
A novel bioactive 31-amino acid endothelin-1 is a potent chemotactic peptide for human neutrophils and monocytes
Autore:
Cui, P; Tani, K; Kitamura, H; Okumura, Y; Yano, M; Inui, D; Tamaki, T; Sone, S; Kido, H;
Indirizzi:
Univ Tokushima, Inst Enzyme Res, Div Enzyme Chem, Tokushima 7708503, JapanUniv Tokushima Tokushima Japan 7708503 me Chem, Tokushima 7708503, Japan Univ Tokushima, Dept Internal Med 3, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 l Med 3, Tokushima 7708503, Japan Univ Tokushima, Sch Med, Dept Pharmacol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 armacol, Tokushima 7708503, Japan
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 2, volume: 70, anno: 2001,
pagine: 306 - 312
SICI:
0741-5400(200108)70:2<306:ANB3AE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; 31-AMINO-ACID-LENGTH ENDOTHELINS; VASOCONSTRICTOR PEPTIDE; BIG ENDOTHELIN-1; CELLS; CHEMOATTRACTANTS; RECEPTOR; CHYMASE; LUNG; PURIFICATION;
Keywords:
chemotaxis; endothelin-1(1-31); endothelin-1(1-21); Ca2(+) mobilization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kido, H Univ Tokushima, Inst Enzyme Res, Div Enzyme Chem, Kuramotocho 3-18-15, Tokushima 7708503, Japan Univ Tokushima Kuramotocho 3-18-15 TokushimaJapan 7708503 Japan
Citazione:
P. Cui et al., "A novel bioactive 31-amino acid endothelin-1 is a potent chemotactic peptide for human neutrophils and monocytes", J LEUK BIOL, 70(2), 2001, pp. 306-312

Abstract

Endothelin (ET)-1(1-31) is a novel 31-amino acid-length peptide derived from big ET-1 by chymase or other chymotrypsin-type proteases and is a major ET derivative in human neutrophils. In this study, we revealed that ET-1(1-31), but not big ET, exhibited chemotactic activities toward human neutrophils and monocytes as an inflammatory mediator, although the effects were less potent than those of formyl-methionyl-leucyl-phenylalanine or interleukin-8. However, the chemotactic effects of ET-1(1-31) were much greater than those of the 21-amino acid ET-1, ET-1(1-21). Checkerboard analyses revealedthat the effects are chemotactic rather than chemokinetic. The effects of ET-1(1-31) are not mediated by interleukin-8 or monocyte chemoattractant protein-1. The chemotactic effects and an increase in intracellular-free Ca2caused by ET-1(1-31) were significantly inhibited by BQ123, an ETA receptor antagonist, but not by BQ788, an ETB receptor antagonist, suggesting thatET-1(1-31) mediates chemotaxis through an ETA or ETA-like receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:00:53