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Titolo:
Influence of placental malaria infection and maternal hypergammaglobulinaemia on materno-foetal transfer of measles and tetanus antibodies in a ruralwest African population
Autore:
Okoko, BJ; Wesuperuma, LH; Ota, MOC; Banya, WAS; Pinder, M; Gomez, FS; Osinusi, K; Hart, AC;
Indirizzi:
MRC, Fajara, Gambia MRC Fajara GambiaMRC, Fajara, Gambia Univ Liverpool, Dept Med Microbiol, Liverpool L69 3BX, Merseyside, EnglandUniv Liverpool Liverpool Merseyside England L69 3BX , Merseyside, England Royal Victoria Hosp, Dept Pathol, Banjul, Gambia Royal Victoria Hosp Banjul Gambia ria Hosp, Dept Pathol, Banjul, Gambia Univ Coll Ibadan Hosp, Dept Paediat, Ibadan, Nigeria Univ Coll Ibadan Hosp Ibadan Nigeria osp, Dept Paediat, Ibadan, Nigeria
Titolo Testata:
JOURNAL OF HEALTH POPULATION AND NUTRITION
fascicolo: 2, volume: 19, anno: 2001,
pagine: 59 - 65
SICI:
1606-0997(200106)19:2<59:IOPMIA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL TETANUS; IMMUNIZATION; VACCINATION; PREGNANCY; IMMUNITY; VACCINES; GAMMA;
Keywords:
malaria; hypergammaglobulinaemia; measles; antibodies; tetanus; the Gambia; West Africa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Okoko, BJ MRC Labs, POB 273, Banjul, Gambia MRC Labs POB 273 Banjul Gambia C Labs, POB 273, Banjul, Gambia
Citazione:
B.J. Okoko et al., "Influence of placental malaria infection and maternal hypergammaglobulinaemia on materno-foetal transfer of measles and tetanus antibodies in a ruralwest African population", J HEALTH PO, 19(2), 2001, pp. 59-65

Abstract

Placental malaria infection jeopardizes pregnancy outcome, and its influence may also impair the transplacental transfer of some antibodies. Two hundred and thirteen Gambian mother-baby pairs were studied to determine the influence of placental malaria infection and maternal hypergammaglobulinaemiaon transplacental transfer of measles and tetanus antibodies in Gambian population. Placental blood and tissue were collected for placental malaria diagnosis. Cord and maternal sera were tested for total IgG concentration bylaser nephelometry and for IgG antibody to tetanus toxoid and measles by ELISA. The prevalence of placental malaria infection was 51.1 %. Mothers whose placentae were parasitized had a significantly higher mean total serum IgG (22.0 g/L vs 11.3 g/L, p <0.001) and measles antibody level (4.02 IU/mL vs 1.21 IU/mL, p <0.01), but not tetanus antibody, than mothers with non-parasitized placentae. Results of multiple regression analysis showed that placental malaria infection and maternal hypergammaglobulinaemia were associated with the reduction of 72% (95% CI 67,84)and 86% (95 % CI 76,91) in transplacental transfer of measles antibody respectively but did not influence the transfer of tetanus antibody. It is concluded that the combined influence of placental malaria infection and maternal hypergammaglobulinaemia is significantly associated with the transfer of impaired measles antibody in this population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:28:21