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Titolo:
Connections of the nucleus incertus
Autore:
Goto, M; Swanson, LW; Canteras, NS;
Indirizzi:
Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo, SP, Brazil Univ Sao Paulo Sao Paulo SP Brazil BR-05508900 BC00 Sao Paulo, SP, Brazil Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 438, anno: 2001,
pagine: 86 - 122
SICI:
0021-9967(20010910)438:1<86:COTNI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAN RAPHE NUCLEUS; WHEAT-GERM AGGLUTININ; LOWER BRAIN-STEM; PHA-L ANALYSIS; LATERODORSAL TEGMENTAL NUCLEUS; AMPHETAMINE-INDUCED LOCOMOTION; MAGNOCELLULAR BASAL FOREBRAIN; MESSENGER-RNA EXPRESSION; RAT-BRAIN; HORSERADISH-PEROXIDASE;
Keywords:
behavioral systems; prefrontal cortex; hippocampal formation; habenular complex; interpeduncular nucleus; median raphe nucleus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Canteras, NS Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, SP, Brazil Univ Sao Paulo AvProf Lineu Prestes 1524 Sao Paulo SP Brazil BR-05508900 BC
Citazione:
M. Goto et al., "Connections of the nucleus incertus", J COMP NEUR, 438(1), 2001, pp. 86-122

Abstract

The nucleus incertus (NI) is a distinct cell group in caudoventral regionsof the pontine periventricular gray, adjacent to the ventromedial border of the caudal dorsal tegmental nucleus. Recent interest in the NI stems fromevidence that it represents one of the periventricular sites with the highest expression levels of mRNA encoding the type 1 corticotropin-releasing hormone (CRH) receptor, which has a high affinity for naturally occurring CRH, perhaps accounting for some of the extrapituitary actions of the peptideon autonomic and behavioral components of the stress response. However, almost nothing is known about NI function and hodological relationships. In this paper, we present the results of a systematic analysis of NI inputs andoutputs using cholera toxin B subunit as a retrograde tracer and Phaseolusvulgaris-leucoagglutinin as an anterograde tracer. Our retrograde tracer experiments indicate that the NI is in a strategic position to integrate information related to behavioral planning (from the prefrontal cortex), lateral habenular processing, hippocampal function, and oculomotor control. Based on its efferent connections, the NI is in a position to exert significantmodulating influences on prefrontal and hippocampal cortical activity; andthe nucleus is also in a position to influence brain sites known to control locomotor behavior, attentive states, and learning processes. Overall; the present results support the idea that the NI is a distinct region of the pontine periventricular gray, and together with the superior central (median raphe) and interpeduncular nuclei the NI appears to form a midline behavior control network of the brainstem.

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Documento generato il 01/12/20 alle ore 00:54:16