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Titolo:
Absence of CCND 1 gene amplification in breast tumours of BRCA1 mutation carriers
Autore:
Vaziri, SAJ; Tubbs, RR; Darlington, G; Casey, G;
Indirizzi:
Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 c Biol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Clin Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Univ Guelph, Dept Math & Stat, Guelph, ON N1G 2X5, Canada Univ Guelph Guelph ON Canada N1G 2X5 h & Stat, Guelph, ON N1G 2X5, Canada
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 4, volume: 54, anno: 2001,
pagine: 259 - 263
SICI:
1366-8714(200108)54:4<259:AOC1GA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; CYCLIN D1 EXPRESSION; OVARIAN-CANCER; CELL-CYCLE; CARCINOMA; WOMEN; OVEREXPRESSION; PROGRESSION; PROGNOSIS; ONCOGENE;
Keywords:
CCND1; HER2; BRCA1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Casey, G Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, 9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 195 USA
Citazione:
S.A.J. Vaziri et al., "Absence of CCND 1 gene amplification in breast tumours of BRCA1 mutation carriers", J CL PATH-M, 54(4), 2001, pp. 259-263

Abstract

Background/Aims It was recently reported that significantly fewer breast tumours of BRCA1 mutation carriers overexpressed cyclin D1 and HER2 protein than tumours of age matched breast cancer cases unselected for family history. This study aimed to examine the genetic basis of this reduction by determining the frequency of tumours within this cohort showing DNA amplification of these genes. Methods-Paraffin wax embedded sections of breast tumours from BRCA1 mutation carriers and age, grade, histological type, and tumour size matched non-familial controls that had previously been stained for cyclin D1 and HER2 protein overexpression were analysed for CCND1 and HER2 gene amplification using fluorescence in situ hybridisation. Results-CCND1 amplification was detected in none of the 30 tumours of the BRCA1 mutation carriers and in 19 of 74 tumours of the matched controls. Ofthose samples previously determined to overexpress the HER2 protein, HER2 amplification was detected in one of three tumours from BRCA1 mutation carriers and in 13 of 17 tumours of the age matched nonfamilial cases. Conclusion-None of the tumours of BRCA1 mutation carriers showed CCND1 amplification and only one tumour showed HER2 amplification. In contrast, a large proportion of cyclin D1 and HER2 overexpression in tumours of non-familial breast cancer cases could be accounted for by amplification of these genes. These data suggest that breast tumorigenesis in BRCA1 mutation carriers occurs by a molecular mechanism distinct from that of age matched non-familial cases.

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Documento generato il 29/03/20 alle ore 00:35:13