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Titolo:
What we could do now: molecular pathology of colorectal cancer
Autore:
Houlston, RS;
Indirizzi:
Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England Inst Canc Res Sutton Surrey England SM2 5NG tton SM2 5NG, Surrey, England
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 4, volume: 54, anno: 2001,
pagine: 206 - 214
SICI:
1366-8714(200108)54:4<206:WWCDNM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; ABERRANT CRYPT FOCI; FAMILIAL ADENOMATOUS POLYPOSIS; P53 NUCLEAR OVEREXPRESSION; RAS POINT MUTATIONS; MICROSATELLITE INSTABILITY; PROGNOSTIC-SIGNIFICANCE; ALLELIC LOSS; K-RAS; COLON-CANCER;
Keywords:
colorectal cancer; prognosis; genes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: Houlston, RS Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England Inst Canc Res Sutton Surrey England SM2 5NG Surrey, England
Citazione:
R.S. Houlston, "What we could do now: molecular pathology of colorectal cancer", J CL PATH-M, 54(4), 2001, pp. 206-214

Abstract

The contribution of molecular genetics to colorectal cancer has been largely restricted to relatively rare inherited tumours and to the detection of germ line mutations predisposing to these cancers. However, much is now known about the somatic events leading to colorectal cancer in general. Several studies have examined the relation between genetic features and prognosis. The purpose of this article is to review these studies and summarise the current state of this subject. Although many of the published studies are small and inconclusive, it is clear that several different pathways exist for the development of this cancer, and some molecular characteristics seem to correlate with clinicopathological features. At present, studies are confined to evaluating a small number of molecular markers; however, with the advent of methods for the rapid genetic profiling of large numbers of colorectal cancers, it will be possible to evaluate fully the clinical usefulnessof a range of colorectal cancer genotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:29:52