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Titolo:
Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunohistochemical analysis in the comparison between benign and malignant components
Autore:
Watanabe, T; Oda, Y; Tamiya, S; Masuda, K; Tsuneyoshi, M;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol Pathol Sci, Higashi Ku, Fukuoka, Japan Kyushu Univ Fukuoka Japan Pathol Pathol Sci, Higashi Ku, Fukuoka, Japan Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka, Japan Kyushu Univ Fukuoka Japan Sch Med Sci, Dept Clin Radiol, Fukuoka, Japan
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY
fascicolo: 8, volume: 54, anno: 2001,
pagine: 631 - 636
SICI:
0021-9746(200108)54:8<631:MPNSTA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTE GROWTH-FACTOR; C-MET PROTOONCOGENE; RAT SCHWANN-CELLS; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; NUCLEAR ANTIGEN; SUPPRESSOR GENE; FACTOR-BETA; EXPRESSION; SYSTEM; CHROMOSOME-17;
Keywords:
malignant peripheral nerve sheath tumour; neurofibroma; immunohistochemistry; transforming growth factor beta; hepatocyte growth factor; p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuneyoshi, M Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol Pathol Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan i, Fukuoka, Japan
Citazione:
T. Watanabe et al., "Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunohistochemical analysis in the comparison between benign and malignant components", J CLIN PATH, 54(8), 2001, pp. 631-636

Abstract

Aims-To compare the expression of immunohistochemical variables between benign and malignant components of malignant peripheral nerve sheath tumour (MPNST) arising within neurofibroma. Methods-Eight cases of MPNST arising within a neurofibroma, associated with neurofibromatosis type 1 (NF1), were studied. The areas of MPNST and neurofibroma were compared immunohistochemically with regard to the expression of proliferative activity (MIB-1), growth factors, p53, bcl-2, neural cell adhesion molecule (N-CAM), and CD34. Results-The expression of transforming growth factor beta1 (TGF-beta1), TGF-beta receptor type II, hepatocyte growth factor alpha (HGF-alpha), c-met,p53, and N-CAM was higher in the areas of MPNST than in the neurofibromatous areas in four, five, five, eight, five, and three of the eight cases, respectively. CD34 expression was lower in the areas of MPNST than in the neurofibroma areas in three of the eight cases. Conclusions-On the basis of these findings, TGF-beta1, HGF-alpha, and p53 might be involved in the malignant transformation of neurofibroma, to MPNST.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:12:58