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Titolo:
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
Autore:
Dimmeler, S; Aicher, A; Vasa, M; Mildner-Rihm, C; Adler, K; Tiemann, M; Rutten, H; Fichtlscherer, S; Martin, H; Zeiher, AM;
Indirizzi:
Univ Frankfurt, Dept Med 4, Div Mol Cardiol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 iol, D-60590 Frankfurt, Germany Aventis Pharmaceut, Frankfurt, Germany Aventis Pharmaceut Frankfurt Germany tis Pharmaceut, Frankfurt, Germany Univ Frankfurt, Dept Med 3, Div Hematol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 matol, D-6000 Frankfurt, Germany
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 3, volume: 108, anno: 2001,
pagine: 391 - 397
SICI:
0021-9738(200108)108:3<391:HRI(IE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE AKT; POSTNATAL NEOVASCULARIZATION; STEM-CELLS; ANGIOGENESIS; PHOSPHORYLATION; DISEASE; ATHEROSCLEROSIS; VASCULOGENESIS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Dimmeler, S Univ Frankfurt, Dept Med 4, Div Mol Cardiol, Theodor Stern Kai7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
S. Dimmeler et al., "HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway", J CLIN INV, 108(3), 2001, pp. 391-397

Abstract

HMG-CoA reductase inhibitors (statins) have been developed as lipid-lowering drugs and are well established to reduce morbidity and mortality from coronary artery disease. Here we demonstrate that statins potently augment endothelial progenitor cell differentiation in mononuclear cells and CD34-positive hematopoietic stem cells isolated from peripheral blood. Moreover, treatment of mice with statins increased c-kit(+)/Sca-1(+)-positive hematopoietic stem cells in the bone marrow and further elevated the number of differentiated endothelial progenitor cells (EPCs). Statins induce EPC differentiation via the PI 3-kinase/Akt (PI3K/Akt) pathway as demonstrated by the inhibitory effect of pharmacological PI3K blockers or overexpression of a dominant negative Akt construct. Similarly, the potent angiogenic growth factor VEGF requires Akt to augment EPC numbers, suggesting an essential role for Akt in regulating hematopoietic progenitor cell differentiation. Given that statins are at least as potent as VEGF in increasing EPC differentiation, augmentation of circulating EPC might importantly contribute to the well-established beneficial effects of statins in patients with coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:26:32