Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Determination of mevalonic acid in human urine as mevalonic acid lactone by gas chromatography-mass spectrometry
Autore:
Woollen, BH; Holme, PC; Northway, WJ; Martin, PD;
Indirizzi:
Syngenta CTL, Macclesfield SK10 4TJ, Cheshire, England Syngenta CTL Macclesfield Cheshire England SK10 4TJ TJ, Cheshire, England AstraZeneca Pharmaceut, Macclesfield, Cheshire, England AstraZeneca Pharmaceut Macclesfield Cheshire England , Cheshire, England
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 760, anno: 2001,
pagine: 179 - 184
SICI:
1387-2273(20010825)760:1<179:DOMAIH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-PLASMA; QUANTITATION;
Keywords:
mevalonic acid; mevalonic acid lactone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Woollen, BH Syngenta CTL, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England Syngenta CTL Alderley Pk Macclesfield Cheshire England SK10 4TJ
Citazione:
B.H. Woollen et al., "Determination of mevalonic acid in human urine as mevalonic acid lactone by gas chromatography-mass spectrometry", J CHROMAT B, 760(1), 2001, pp. 179-184

Abstract

Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes inurinary excretion of MVA following administration of drugs which affect cholesterol synthesis. The assay is linear up to 300 ng/ml and has acceptableprecision (<15%) and accuracy (<+/-20%) across the calibration range. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:39:52