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Titolo:
Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection
Autore:
Nakashima, A; Saxer, C; Niina, M; Masuda, N; Iwasaki, K; Furukawa, K;
Indirizzi:
Novartis Pharma KK, Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan Novartis Pharma KK Tsukuba Ibaraki Japan 3002611 , Ibaraki 3002611, Japan Chem Evaluat & Res Inst, Kurume, Fukuoka 8300023, Japan Chem Evaluat & ResInst Kurume Fukuoka Japan 8300023 kuoka 8300023, Japan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 760, anno: 2001,
pagine: 17 - 25
SICI:
1387-2273(20010825)760:1<17:DOFAIF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
REDUCTASE INHIBITOR; BLOOD-PLASMA; ENANTIOMERS; THERAPY; LIPIDS; DRUG;
Keywords:
metabolites; fluvastatin; HMG CoA reductase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Nakashima, A Novartis Pharma KK, Tsukuba Res Inst, Ohkubo 8, Tsukuba, Ibaraki 3002611, Japan Novartis Pharma KK Ohkubo 8 Tsukuba Ibaraki Japan 3002611 pan
Citazione:
A. Nakashima et al., "Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection", J CHROMAT B, 760(1), 2001, pp. 17-25

Abstract

A simple gradient reversed-phase high-performance chromatographic method with ultraviolet detection for the determination of fluvastatin (FV) and itsfive metabolites, (M-2, M-3, M-4, M-5 and M-7) in human plasma was developed and validated. The limit of quantification of FV and its five metabolites in human plasma was 10 ng ml(-1). The assay had satisfactory selectivity,recovery, linearity and precision accuracy. Stability studies showed that FV and its five metabolites were stable in plasma up to at least 1 month ofstorage at -30 degreesC. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:50:21