Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased levels of tissue plasminogen activator antigen and factor VIII activity in nonvalvular atrial fibrillation: Relation to predictors of thromboembolism
Autore:
Wang, TD; Chen, WJ; Su, SSY; Su, TC; Chen, MF; Liau, CS; Lee, YT;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, Taipei 100, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 100 Med Cardiol, Taipei 100, Taiwan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 8, volume: 12, anno: 2001,
pagine: 877 - 884
SICI:
1045-3873(200108)12:8<877:ILOTPA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-PHASE REACTION; RISK FACTOR; ANGINA-PECTORIS; MITRAL-STENOSIS; MYOCARDIAL-INFARCTION; COAGULATION ACTIVITY; FOLLOW-UP; STROKE; MARKERS; ASPIRIN;
Keywords:
atrial fibrillation; coagulation; plasminogen activators; risk factors; thromboembolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, YT Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, 7 Chung Shan S Rd, Taipei 100, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 Taiwan
Citazione:
T.D. Wang et al., "Increased levels of tissue plasminogen activator antigen and factor VIII activity in nonvalvular atrial fibrillation: Relation to predictors of thromboembolism", J CARD ELEC, 12(8), 2001, pp. 877-884

Abstract

Introduction: Given that nonvalvular atrial fibrillation (AF)-associated stroke can be either cardioembolic or atherothrombotic, we investigated the relationships between nonvalvular AF and hemostatic factors reflecting intrinsic thrombogenic and atherogenic potentials (tissue plasminogen activator[t-PA] antigen, plasminogen activator inhibitor-1, and factor VIII activity). We also evaluated the clinical applicability of these hemostatic factors by examining whether AF subjects with established clinical or echocardiographic predictors of thromboembolism had higher levels of these factors. Methods and Results: Of the 3,212 participants of a Chinese population-based study, 53 subjects (1.7 %) with AF were identified. Among the hemostaticfactors measured, t-PA antigen (median 12.8 vs 8.1 ng/mL; P < 0.01) and factor VIII activity (median 155% vs 133%; P < 0.05) were significantly higher in AF subjects after adjustment for age and sex. In multivariate analysis, features independently associated with t-PA antigen levels were AF, age, sex, body mass index, systolic blood pressure, total cholesterol, triglycerides, and left ventricular systolic dysfunction. Features independently associated with factor VIII activity levels included AF, age, and total cholesterol. Levels of both t-PA antigen and factor VIII activity were primarily elevated in AF subjects with predictors of thromboembolism (age > 75 years,hypertension, diabetes, and left ventricular systolic dysfunction), whereas in AF subjects with no thromboembolic predictors, plasma levels of hemostatic factors examined were similar to those without AF. Conclusion: We demonstrated that nonvalvular AF was independently associated with increased peripheral levels of t-PA antigen and factor VIII activity. Levels of both hemostatic factors were primarily elevated in AF subjectswith predictors of thromboembolism. Whether these hemostatic factors are independently predictive of future thromboembolic events in AF patients requires further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:45:36