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Titolo:
Retention and transit of intestinal mucoadhesive films in rat small intestine
Autore:
Eaimtrakarn, S; Itoh, Y; Kishimoto, J; Yoshikawa, Y; Shibata, N; Takada, K;
Indirizzi:
Kyoto Pharmaceut Univ, Dept Pharmacokinet, Yamashima Ku, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 shima Ku, Kyoto 6078414, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 224, anno: 2001,
pagine: 61 - 67
SICI:
0378-5173(20010814)224:1-2<61:RATOIM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED-RELEASE MICROSPHERES; POLYGLYCEROL ESTERS; ORAL DELIVERY; FATTY-ACIDS; ABSORPTION; DRUGS; FORMULATIONS; HORMONE; PEPTIDE; PROTEIN;
Keywords:
mucoadhesive; film system; retention; small intestine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Takada, K Kyoto Pharmaceut Univ, Dept Pharmacokinet, Yamashima Ku, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 Kyoto 6078414, Japan
Citazione:
S. Eaimtrakarn et al., "Retention and transit of intestinal mucoadhesive films in rat small intestine", INT J PHARM, 224(1-2), 2001, pp. 61-67

Abstract

The retention and transit characteristics of intestinal mucoadhesive film systems have been studied after intraduodenal administration in rats. Smallsize four layered film preparations, 0.5 x 0.5 mm, were prepared, where the backing layer (45.1 +/- 2.9 mum thick) was made of a water-insoluble polymer, ethylcellulose (EC), the surface layer was made of enteric pH-sensitive polymers, Eudragit (R) L100, SIN or HP-55 (R) and the middle layer was made of cellulose membrane. The surface layer was attached to the middle layer with an adhesive layer composed of carboxyvinyl polymer (Hiviswako (R) 103). After administration of ten films to the duodenum, the rats were sacrificed hourly and the distribution of the films in the whole small intestine was directly observed after abdominal incision. The HP-55, Eudragit L100 and S100 film systems were found to adhere to the upper, middle and lower part of the small intestine after 1, 2 and 4 h, respectively, for 2-3 h. Direct inspection study suggests that intestinal mucoadhesive film system has functions of. (1) pH-dependent intestinal adhesion site specificity; (2) adhesion to the intestinal wall; and (3) retention in the small intestinal adhesion site for at least 2 h. Intestinal mucoadhesive film system has been suggested to be a targeting system for drugs to the gastrointestinal tract. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:32:44