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Titolo:
Hair as a biological specimen for therapeutic drug monitoring
Autore:
Beumer, JH; Bosman, IJ; Maes, R;
Indirizzi:
Univ Utrecht, Fac Pharm, Dept Biomed Anal, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands Dept Biomed Anal, Utrecht, Netherlands
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
fascicolo: 6, volume: 55, anno: 2001,
pagine: 353 - 357
SICI:
1368-5031(200107/08)55:6<353:HAABSF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SCALP HAIR; INDIVIDUAL DOSAGE HISTORY; PERFORMANCE LIQUID-CHROMATOGRAPHY; REDUCED HALOPERIDOL; TIME-MARKER; ANTIMICROBIAL QUINOLONE; INDEX; OFLOXACIN; CARBAMAZEPINE; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bosman, IJ Netherlands Forens Inst, Dept Toxicol, Volmerlaan 17, NL-2288 GD Rijswijk,Netherlands Netherlands Forens Inst Volmerlaan 17 Rijswijk Netherlands NL-2288 GD
Citazione:
J.H. Beumer et al., "Hair as a biological specimen for therapeutic drug monitoring", INT J CL PR, 55(6), 2001, pp. 353-357

Abstract

To study the potential of hair as a biological specimen in therapeutic drug monitoring (TDM), a review of the correlation between hair concentration,blood levels, dose and therapeutic effects of various drugs is presented. The results indicate there is a fair correlation between plasma and hair for several medicines. Moreover, hair samples have the advantage of providinginformation of more prolonged drug intake, thus allowing a better evaluation of patient compliance. Using segmental hair analysis, only a single sample is necessary We conclude that hair has potential as a biological specimen in TDM - at least as far as compliance is concerned and possibly as a longer term record of drug concentrations - and that correlation between hair concentration, blood levels and clinical efficacy should be investigated for all drugs where TDM is indicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 04:48:36