Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Low risk of significant echocardiographic valvulopathy in patients treatedwith anorectic drugs
Autore:
Burger, AJ; Charlamb, MJ; Singh, S; Notarianni, M; Blackburn, GL; Sherman, HB;
Indirizzi:
Beth Israel Deaconess Med Ctr, Noninvas Cardiol Lab, Div Cardiol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 l, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Study Nutr Med, Boston, MA USA Harvard Univ Boston MA USA s Med Ctr, Ctr Study Nutr Med, Boston, MA USA
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOLOGY
fascicolo: 2-3, volume: 79, anno: 2001,
pagine: 159 - 165
SICI:
0167-5273(200107)79:2-3<159:LROSEV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOID HEART-DISEASE; VALVULAR ABNORMALITIES; VALVE ABNORMALITIES; OBESE PATIENTS; PREVALENCE; DEXFENFLURAMINE; REGURGITATION; INSUFFICIENCY; FENFLURAMINE; DETERMINANTS;
Keywords:
valvular disease; aortic regurgitation; mitral regurgitation; phentermine; fenfluramine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Burger, AJ Beth Israel Deaconess Med Ctr, Noninvas Cardiol Lab, Div Cardiol, Baker 3,1 Deaconess Rd, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Baker 3,1 Deaconess Rd Boston MA USA 02215
Citazione:
A.J. Burger et al., "Low risk of significant echocardiographic valvulopathy in patients treatedwith anorectic drugs", INT J CARD, 79(2-3), 2001, pp. 159-165

Abstract

Background: Phentermine-fenfluramine and dexfenfluramine use for weight loss has been previously associated with increased prevalence of valvular heart disease. This association was initially based on small numbers of patients, limited data on dose and duration of drug therapy, and no correlation with matched controls. Methods: Our investigation involved 343 obese subjects enrolled in a prospective, strict weight loss, research protocol from September 1994 to September 1997. All subjects underwent transthoracic echocardiography for significant valvular lesions within a mean of 121 days from the manufacturer's announcement of the voluntary withdrawal of fenfluramine and dexfenfluramine from the market. All echocardiograms were interpreted by 2 independent readers. Results: The study population included 281 femalesand 62 males with a mean age of 46.7 +/- 9.1 years and mean initial body mass index of 40.1 +/- 8.1 kg/m(2). Using the Food and Drug Administration'scriteria, only 21 subjects (6.1%) had significant valvular lesions. Aorticregurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in I subject; no one had severe regurgitation. Significant valvular disease did not correlate with age, gender, initial/ending body mass index, the drug dose, duration of drug therapy, or serotonin reuptake inhibitors. Conclusions: Anorexigen therapy is associated with a low prevalence of significant valvular regurgitation. Late valvular abnormalities from drug treatment await long term prospective studies. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:48:38