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Titolo:
Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis
Autore:
Sheard, AA;
Indirizzi:
Masaryk Mem Canc Inst, Dept Cellular & Mol Oncol, Brno 65653, Czech Republic Masaryk Mem Canc Inst Brno Czech Republic 65653 no 65653, Czech Republic
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 4, volume: 96, anno: 2001,
pagine: 213 - 220
SICI:
0020-7136(20010820)96:4<213:IRAARA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FAS-MEDIATED APOPTOSIS; IRRADIATION-INDUCED APOPTOSIS; FLICE-INHIBITORY PROTEIN; STRESS-INDUCED APOPTOSIS; PERFORIN-DEFICIENT MICE; NATURAL-KILLER-CELLS; MURINE RENAL-CANCER; CD8(+) T-CELLS; CARCINOMA-CELLS;
Keywords:
CD95/Fas/APO-1; ionizing radiation; apoptosis; p53/Trp53;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Sheard, AA Masaryk Mem Canc Inst, Dept Cellular & Mol Oncol, Zluty Kopec 7, Brno 65653, Czech Republic Masaryk Mem Canc Inst Zluty Kopec 7 Brno Czech Republic 65653
Citazione:
A.A. Sheard, "Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis", INT J CANC, 96(4), 2001, pp. 213-220

Abstract

CD95 (Fas/APO-1) is a death receptor on the surface of a wide variety of cell types. In most cells examined, ionizing radiation acts as a response-enhancing agent for CD95-mediated cell death. Although DNA-damaging radiationappears to modulate CD95-mediated signals through multiple mechanisms, theonly well-characterized mechanism is activation of the tumor-suppressor protein p53, which transcriptionally regulates the expression of CD95 on various cell types. The ligand for CD95 is expressed by activated lymphocytes and natural-killer cells, which produce factors that sensitize cells resistant to CD95-mediated cell death. Ligation of CD95 on irradiated tumor cells might be achievable using emerging modalities that reactivate the stalled anti-tumor immune response. ( C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:13:04