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Titolo:
Mast cells and nitric oxide: control of production, mechanisms of response
Autore:
Forsythe, P; Gilchrist, M; Kulka, M; Befus, AD;
Indirizzi:
Univ Alberta, Pulm Res Grp, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 Grp, Edmonton, AB T6G 2S2, Canada
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 8, volume: 1, anno: 2001,
pagine: 1525 - 1541
SICI:
1567-5769(200108)1:8<1525:MCANOC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP CYCLOHYDROLASE-I; FEEDBACK REGULATORY PROTEIN; SOLUBLE GUANYLATE-CYCLASE; SYNTHASE MESSENGER-RNA; HISTAMINE-RELEASE; INTERFERON-GAMMA; PROINFLAMMATORY CYTOKINES; ENDOTHELIAL-CELLS; SMOOTH-MUSCLE; K+ CHANNELS;
Keywords:
mast cell; nitric oxides; regulation; ion channel;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
109
Recensione:
Indirizzi per estratti:
Indirizzo: Befus, AD Univ Alberta, Pulm Res Grp, 574 Heritage Med Res Ctr, Edmonton, AB T6G 2S2, Canada Univ Alberta 574 Heritage Med Res Ctr Edmonton AB CanadaT6G 2S2
Citazione:
P. Forsythe et al., "Mast cells and nitric oxide: control of production, mechanisms of response", INT IMMUNO, 1(8), 2001, pp. 1525-1541

Abstract

Mast cells are involved in numerous activities ranging from control of thevasculature, to tissue injury and repair, allergic inflammation and host defences. They synthesize and secrete a variety of mediators, activating andmodulating the functions of nearby cells and initiating complex physiological changes. Interestingly, NO produced by mast cells and/or other cells inthe microenvironment appears to regulate these diverse roles. This review outlines some of the pathways central to the production of NO by mast cellsand identifies many of the tightly controlled regulatory mechanisms involved. Several cofactors and regulatory elements are involved in NO production, and these act at transcriptional and post-translational sites. Their involvement in NO production will be outlined and the possibility that these pathways are critically important in mast cell functions will be discussed. The effects of NO on mast cell functions such as adhesion, activation and mediator secretion will be examined with a focus on molecular mechanisms by which NO modifies intracellular signalling pathways dependent or independentof cGMP and soluble guanylate cyclase. The possibility that NO regulates mast cell function through effects on selected ion channels will be discussed. Metabolic products of NO including peroxynitrite and other reactive species may be the critical elements that affect the actions of NO on mast cellfunctions. Further understanding of the actions of NO on mast cell activities may uncover novel strategies to modulate inflammatory conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:43:19