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Titolo:
Natural killer cells and nitric oxide
Autore:
Cifone, MG; Ulisse, S; Santoni, A;
Indirizzi:
Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 Dept Expt Med, I-67100 Laquila, Italy Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy Univ Roma La Sapienza Rome Italy a, Dept Expt Med & Pathol, Rome, Italy
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 8, volume: 1, anno: 2001,
pagine: 1513 - 1524
SICI:
1567-5769(200108)1:8<1513:NKCANO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA PRODUCTION; CLASS-I MOLECULES; NECROSIS-FACTOR-ALPHA; HUMAN NK CELLS; L-ARGININE; SIGNAL-TRANSDUCTION; TARGET-CELL; MONOCLONAL-ANTIBODY; UTERINE LEUKOCYTES; CYTOTOXIC FUNCTION;
Keywords:
natural killer cells; nitric oxide; cell activation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Cifone, MG Univ Aquila, Dept Expt Med, Via Vetoio,10 Coppito 2, I-67100 Laquila, Italy Univ Aquila Via Vetoio,10 Coppito 2 Laquila Italy I-67100 taly
Citazione:
M.G. Cifone et al., "Natural killer cells and nitric oxide", INT IMMUNO, 1(8), 2001, pp. 1513-1524

Abstract

Natural killer (NK) cells and nitric oxide (NO) are both important components of the natural or innate immune response. NK cells are large granular lymphocytes capable of destroying cells infected by virus or bacteria and susceptible tumor cells without prior sensitization and restriction by MHC antigens. They are abundant in blood, spleen, liver and lungs and are distinct from both T and B lymphocytes in their circulation patterns, profile of surface antigens, receptor repertoire and the way in which they discriminatebetween self and non-self. Uniquely, NK cells express receptors that can recognize and discriminate between normal and altered MHC class I determinants. NK cell cytotoxic activity is strongly induced by cytokines such as IL-2 and IL-12, and this activation is associated with synthesis of NO. Inhibitors of NO synthesis impair NK cell-mediated target cell killing, demonstrating a role for NO in NK cell function. Furthermore, NO itself can regulateNK cell activation. In this article, evidence that NO is a mediator of NK cell-mediated target cell killing, and that NO is a regulator of NK cell activation will be reviewed. Results of NO synthase gene deletion studies will be discussed, and rodent and human NK cells will be compared. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:30:10