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Titolo:
The physiological role and pharmacological potential of nitric oxide in neutrophil activation
Autore:
Armstrong, R;
Indirizzi:
Queen Margaret Univ Coll, Ctr Food & Nutr Res, Dept Dietet Nutr & Biol Sci, Edinburgh EH12 8TS, Midlothian, Scotland Queen Margaret Univ Coll Edinburgh Midlothian Scotland EH12 8TS Scotland
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 8, volume: 1, anno: 2001,
pagine: 1501 - 1512
SICI:
1567-5769(200108)1:8<1501:TPRAPP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; LUMINOL-DEPENDENT CHEMILUMINESCENCE; MYOCARDIAL ISCHEMIA-REPERFUSION; RESPIRATORY-DISTRESS-SYNDROME; CYCLIC-GMP; L-ARGININE; SYNTHASE INHIBITORS; SUPEROXIDE ANION; PROTEIN-KINASE; ENDOTHELIAL FUNCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
109
Recensione:
Indirizzi per estratti:
Indirizzo: Armstrong, R Queen Margaret Univ Coll, Ctr Food & Nutr Res, Dept Dietet Nutr & Biol Sci, Clerwood Terrace, Edinburgh EH12 8TS, Midlothian, Scotland Queen Margaret Univ Coll Clerwood Terrace Edinburgh Midlothian Scotland EH128TS
Citazione:
R. Armstrong, "The physiological role and pharmacological potential of nitric oxide in neutrophil activation", INT IMMUNO, 1(8), 2001, pp. 1501-1512

Abstract

There is contention over whether human neutrophils produce physiologicallysignificant levels of nitric oxide (NO) during inflammatory reactions. Nevertheless, regardless of its cell source, NO does exert regulatory effects on neutrophil function. Depending on experimental conditions, NO can eitherinhibit or enhance neutrophil activation, in both cases probably acting through cyclic GMP. The explanation for these apparently contradictory findings may be that the effect depends upon the concentration of NO: low concentrations of NO being stimulatory and high concentrations inhibitory. Nitrite, produced at high concentrations from NO during inflammation, can react with neutrophil myeloperoxidase-derived hypochlorous acid (HOCl) to form the active oxidant nitryl chloride, a species capable of nitrating tyrosine andtyrosyl residues on proteins. Whether nitryl chloride acts to limit or amplify the oxidant effects of myeloperoxidase is not yet clear, although formation of nitrotyrosine has been linked with nitration of phagocytosed bacteria. Clearly, a better understanding of the inflammatory effects of NO on neutrophils is needed before the therapeutic potential of NO donors or inhibitors in inflammation can be realised. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:25:41