Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nitric oxide and T helper cell immunity
Autore:
van der Veen, RC;
Indirizzi:
Univ So Calif, Sch Med, Dept Neurol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Neurol, Los Angeles, CA 90033 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 8, volume: 1, anno: 2001,
pagine: 1491 - 1500
SICI:
1567-5769(200108)1:8<1491:NOATHC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INTERFERON-GAMMA INDUCTION; MYELIN PROTEOLIPID PROTEIN; CENTRAL-NERVOUS-SYSTEM; SMOOTH-MUSCLE CELLS; IFN-GAMMA; MULTIPLE-SCLEROSIS; DEFICIENT MICE; PERITONEAL-MACROPHAGES;
Keywords:
nitric oxides; T helper cell; superoxide; EAE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: van der Veen, RC Univ So Calif, Sch Med, Dept Neurol, MCH 142,1333 San Pablo St, Los Angeles, CA 90033 USA Univ So Calif MCH 142,1333 San Pablo St Los Angeles CA USA 90033
Citazione:
R.C. van der Veen, "Nitric oxide and T helper cell immunity", INT IMMUNO, 1(8), 2001, pp. 1491-1500

Abstract

In this article, the controversial role of nitric oxide (NO) in T helper (Th) cell activation and T-cell-dependent immunity will be discussed with anemphasis on immunosuppression by NO. NO is generated by antigen-presentingcells (APC) during the process of antigen presentation to T cells. In mouse models, activation of the inducible NO synthase (iNOS) in APC is triggered by Th1-cell-derived IFN-gamma, in combination with other soluble or membrane-associated T-cell factors. The NO so-produced inhibits T-cell proliferation, while it does not inhibit T cell cytokine production. NO blocks T-cell proliferation during G1/S transition. In mouse models of T-cell-mediated autoimmunity such as myelin antigen-induced EAE, the disease is exacerbatedby genetic deletion of iNOS, indicating that NO suppresses T-cell-mediatedimmunity in vivo. Recent studies reveal that interaction with superoxide diminishes the T-cell regulatory activity of NO. The role for NADPH oxidase as a source for NO-inhibiting superoxide is discussed. In conclusion, NO plays an important regulatory role in the induction phase of T-cell-mediated immunity. Superoxide may enhance T-cell-mediated immunity by preventing theimmunosuppressive activity of NO. (C) 2001 Published by Elsevier Science B. V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:32:36