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Titolo:
Nitric oxide in parasitic infections
Autore:
Brunet, LR;
Indirizzi:
Univ Coll London, Dept Bacteriol, Windeyer Inst Med Sci, London WC1E 6BT, England Univ Coll London London England WC1E 6BT d Sci, London WC1E 6BT, England
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 8, volume: 1, anno: 2001,
pagine: 1457 - 1467
SICI:
1567-5769(200108)1:8<1457:NOIPI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHISTOSOMA-MANSONI INFECTION; BRUCEI-RHODESIENSE INFECTIONS; ACUTE CHAGASIC CARDIOMYOPATHY; TRYPANOSOMA-CRUZI INFECTION; TOXOPLASMA-GONDII INFECTION; INTESTINAL EPITHELIAL-CELLS; LEISHMANIA-MAJOR INFECTION; VITRO GRANULOMA-FORMATION; HUMAN CEREBRAL MALARIA; IFN-GAMMA;
Keywords:
nitric oxide; parasitic infections; cytokines;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Brunet, LR Univ Coll London, Dept Bacteriol, Windeyer Inst Med Sci, 46 Cleveland St, London WC1E 6BT, England Univ Coll London 46 Cleveland St London England WC1E 6BT gland
Citazione:
L.R. Brunet, "Nitric oxide in parasitic infections", INT IMMUNO, 1(8), 2001, pp. 1457-1467

Abstract

Nitric oxide (NO) is implicated as an integral component of the host armament against invading parasites. Strongest evidence has come from laboratorymodels of protozoan infections. During malaria, toxoplasmosis and leishmaniasis, to name just a few, the preferential production of pro-inflammatory cytokines predisposes to the increased synthesis of NO, which mediates hostprotection through either direct parasite killing or by limiting parasite growth. More recently, evidence has been put forward for a beneficial role of NO during helminthic infections. In the case of Schistosomiasis mansoni,for example, NO plays a role in regulation of egg-induced inflammation, preventing hepatocyte death and widespread tissue damage. In spite of these findings, rather than being the ultimate panacea, NO production requires tight control to limit cytotoxic damage to the host's own cells. Unregulated production may lead to a variety of damaging effects including alterations to normal neurological functions during cerebral malaria and intestinal pathology during trichinosis. In this review, I will summarize the role of NO during a number of parasitic infections, drawing on specific examples of disease caused by protozoan and metazoan parasites. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:28:55