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Titolo:
Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: Association with leukocytosis and hypercalcemia
Autore:
Hayashi, T; Mizuki, A; Yamaguchi, T; Hasegawa, T; Kunihiro, T; Tsukada, N; Matsuoka, K; Orikasa, H; Yamazaki, K;
Indirizzi:
Tokyo Saiseikai Cent Hosp, Dept Internal Med, Minato Ku, Tokyo 1080073, Japan Tokyo Saiseikai Cent Hosp Tokyo Japan 1080073 o Ku, Tokyo 1080073, Japan
Titolo Testata:
INTERNAL MEDICINE
fascicolo: 7, volume: 40, anno: 2001,
pagine: 631 - 634
SICI:
0918-2918(200107)40:7<631:PACOTL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER;
Keywords:
primary liver tumor; paraneoplastic syndrome; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukada, N Tokyo Saiseikai Cent Hosp, Dept Internal Med, Minato Ku, 1-4-17Mita, Tokyo 1080073, Japan Tokyo Saiseikai Cent Hosp 1-4-17 Mita Tokyo Japan 1080073 apan
Citazione:
T. Hayashi et al., "Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: Association with leukocytosis and hypercalcemia", INTERN MED, 40(7), 2001, pp. 631-634

Abstract

A 55-year-old man was admitted to our hospital with fever and vomiting. Abdominal computed tomography (CT) revealed multiple low density masses in the liver. A diagnosis of primary adenosquamous carcinoma of the liver was confirmed by histological examination of a necropsy specimen. The present case showed leukocytosis and hypercalcemia with high levels of serum granulocyte-colony-stimulating factor (G-CSF) and parathyroid hormone related protein (PTHrP). Recent studies have shown that G-CSF and PTHrP are responsible for the paraneoplastic syndromes with leukocytosis and hypercalcemia. The tumor cells demonstrated positive cytoplasmic immunohistochemistry staining with anti-G-CSF and anti-PTHrP antibodies. This result suggested that the tumor produced G-CSF and PTHrP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:54:52