Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Molecular biology of polycythemias
Autore:
Prchal, JT;
Indirizzi:
Baylor Coll Med, Div Hematol Oncol, Houston, TX 77030 USA Baylor Coll MedHouston TX USA 77030 Hematol Oncol, Houston, TX 77030 USA
Titolo Testata:
INTERNAL MEDICINE
fascicolo: 8, volume: 40, anno: 2001,
pagine: 681 - 687
SICI:
0918-2918(200108)40:8<681:MBOP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROID PROGENITOR CELLS; HYPOXIA-INDUCIBLE FACTOR-1; GROWTH-FACTOR-I; SERUM-FREE MEDIUM; TRUNCATED ERYTHROPOIETIN RECEPTORS; DOMINANT PRIMARY POLYCYTHEMIA; RENIN-ANGIOTENSIN SYSTEM; TUMOR-SUPPRESSOR PROTEIN; FACTOR-BINDING PROTEIN-1; MYELOPROLIFERATIVE DISORDERS;
Keywords:
erythrocytosis; hypoxia inducible factor (HIF); erythropoietin; hematopoiesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Prchal, JT Baylor Coll Med, Div Hematol Oncol, 1 Baylor Plaza 802E, Houston, TX 77030USA Baylor Coll Med 1 Baylor Plaza 802E Houston TX USA 77030 030USA
Citazione:
J.T. Prchal, "Molecular biology of polycythemias", INTERN MED, 40(8), 2001, pp. 681-687

Abstract

Polycythemia is literally translated as "many cells in the blood". Only erythrocytosis (an alternative term for these disorders) produces polycythemia since leukocytes and platelets are present in blood in far smaller proportions. Polycythemia may be due to increased proliferation or decreased apoptosis of erythroid progenitors, or to delayed erythroid differentiation with an increased number of progenitor cell divisions. Prolonged red cell survival, another theoretical cause of polycythemia, has not yet been describedand with intact regulatory mechanisms is unlikely to occur. Primary polycythemias result from abnormalities expressed in hematopoietic progenitors. In contrast, circulating factors cause secondary polycythemia (1). There areacquired and congenital causes of both primary and secondary polycythemia (1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:28:06