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Titolo:
Biology of T memory type 1 cells
Autore:
Anfossi, N; Pascal, V; Vivier, E; Ugolini, S;
Indirizzi:
CNRS, Inst Pharmacol Mol & Cellulaire, F-06560 Sophia Antipolis, France CNRS Sophia Antipolis France F-06560 e, F-06560 Sophia Antipolis, France Univ Med, CNRS Marseille Luminy, Ctr Immunol, INSERM, F-13288 Marseille, France Univ Med Marseille France F-13288 nol, INSERM, F-13288 Marseille, France Hop Conception, Hematol Serv, Marseille, France Hop Conception MarseilleFrance eption, Hematol Serv, Marseille, France
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 181, anno: 2001,
pagine: 269 - 278
SICI:
0105-2896(200106)181:<269:BOTMT1>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; KILLER INHIBITORY RECEPTORS; NATURAL-KILLER; INTRAEPITHELIAL LYMPHOCYTES; DIFFERENTIAL REGULATION; LYMPHOKINE PRODUCTION; EFFECTOR FUNCTION; PERIPHERAL-BLOOD; KIR EXPRESSION; HEALTHY DONORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Ugolini, S CNRS, Inst Pharmacol Mol & Cellulaire, 660 Route Lucioles, F-06560 Sophia Antipolis, France CNRS 660 Route Lucioles Sophia Antipolis France F-06560 France
Citazione:
N. Anfossi et al., "Biology of T memory type 1 cells", IMMUNOL REV, 181, 2001, pp. 269-278

Abstract

Engagement of inhibitory natural killer (NK) cell receptors for MHC class I molecules (NKR) can impair NK-cell activation programs. Inhibitory NKR thus confer to NK cells the capacity to discriminate between MHC class I+ andMHC class I- target cells, and are therefore involved in the control of NK-cell tolerance to self, as well as in the elimination of MHC class I- distressed cells by NK cells. In human and mouse, a subset of alpha beta T cells also express inhibitory NKR at their surface, but the biological functionof inhibitory NKR on T cells remains to be precisely elucidated. We refer to these cells as T memory type 1 (Tm1) cells, and review here the phenotypic and functional features of this subset of memory-phenotype CD8(+) alpha beta T cells. in vitro studies suggest that inhibitory NKR are involved in the peripheral control of T-cell self-tolerance. In vitro and in vivo analysis have revealed a novel biological function for inhibitory NKR when expressed on T cells. Indeed, engagement of inhibitory NKR on T cells provides them with survival signals against activation-induced cell death. Thus, sensing of self-MHC class I molecules by inhibitory NKR displayed on alpha betaT cells leads to the in vivo accumulation of Tm 1 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:27:26