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Titolo:
Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family
Autore:
Takai, T; Ono, M;
Indirizzi:
Tohoku Univ, Inst Dev Aging & CAnc, Dept Expt Immunol, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 ol, Sendai, Miyagi 9808575, Japan
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 181, anno: 2001,
pagine: 215 - 222
SICI:
0105-2896(200106)181:<215:AAINOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-GAMMA-RIII; CLASS-I MOLECULES; TYROSINE-PHOSPHATASE SHP-1; MAST-CELL DEGRANULATION; DEFICIENT MICE; PIR-B; SYSTEMIC-ANAPHYLAXIS; ARTHUS REACTION; MYELOID CELLS; HIGH-AFFINITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Takai, T Tohoku Univ, Inst Dev Aging & CAnc, Dept Expt Immunol, Seiryo 4-1, Sendai,Miyagi 9808575, Japan Tohoku Univ Seiryo 4-1 Sendai Miyagi Japan 9808575 9808575, Japan
Citazione:
T. Takai e M. Ono, "Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family", IMMUNOL REV, 181, 2001, pp. 215-222

Abstract

Clones for murine paired immunoglobulin-ne receptors (PIR) were first isolated as those coding for type I transmembrane glycoproteins with six immunoglobulin-like domains homologous to human Fc alphaR, bovine Fc gamma 2R, and other related receptors. However, they turned out to bind neither IgA norother immunoglobulins in the case of the ectopic expression on COS-1 fibroblastic cells. PIR-A and B are expressed on a wide variety of cells in the murine immune system, such as in B cells, mast cells, macrophages, and dendritic cells, mostly in a pairwise fashion. PIR-A requires homodimeric Fc receptor common gamma chain, which harbors an immunoreceptor tyrosine-based activation motif, for its efficient cell surface expression and for the delivery of activation signaling. In contrast, PIR-B contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic portion and inhibits receptor-mediated activation signaling in vitro upon engagement with other activating-type receptors such as the antigen receptor on B cells and the high affinity Fc receptor for IgE on mast cells. ITIMs of PIR-B on macrophages and B cells have been shown to be constitutively phosphorylated in their tyrosine residues. Although the ligand for PIR still remains unknown, the transgenics and the gene-targeted mice will provide us with valuable information on their physiological roles in the immune regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:35:37