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Titolo:
Human natural killer cell receptors and co-receptors
Autore:
Biassoni, R; Cantoni, C; Pende, D; Sivori, S; Parolini, S; Vitale, M; Bottino, C; Moretta, A;
Indirizzi:
Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy Univ Genoa GenoaItaly noa, Dipartimento Med Sperimentale, Genoa, Italy Ist Giannina Gaslini, I-16148 Genoa, Italy Ist Giannina Gaslini Genoa Italy I-16148 a Gaslini, I-16148 Genoa, Italy Univ Brescia, Dipartimento Sci Biomed & Biotechnol, I-25121 Brescia, ItalyUniv Brescia Brescia Italy I-25121 & Biotechnol, I-25121 Brescia, Italy
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 181, anno: 2001,
pagine: 203 - 214
SICI:
0105-2896(200106)181:<203:HNKCRA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA CLASS-I; LINKED LYMPHOPROLIFERATIVE-DISEASE; MHC CLASS-I; HUMAN NK CELLS; LEUKOCYTE ANTIGEN (HLA)-CW4; DELTA T-CELLS; INHIBITORY RECEPTOR; IMMUNOGLOBULIN-SUPERFAMILY; MOLECULAR-CLONING; CUTTING EDGE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
155
Recensione:
Indirizzi per estratti:
Indirizzo: Biassoni, R CBA, IST, Immunol Lab, Lgo R Benzi 10, I-16132 Genoa, Italy CBA Lgo R Benzi 10 Genoa Italy I-16132 , I-16132 Genoa, Italy
Citazione:
R. Biassoni et al., "Human natural killer cell receptors and co-receptors", IMMUNOL REV, 181, 2001, pp. 203-214

Abstract

In the absence of sufficient signaling by their HLA class I-specific inhibitory receptors, human natural killer (NK) cells become activated and display potent cytotoxicity against cells that are either HLA class I negative or deficient. This indicates that the NK receptors responsible for the induction of cytotoxicity recognize ligands on target cells different from HLA class I molecules. On this basis, the process of NK-cell triggering can be considered as a mainly non-NMC-restricted mechanism. The recent identification of a group of NK-specific triggering surface molecules has allowed a first series of pioneering studies on the functional/molecular characteristicsof such receptors. The first three members of a receptor family that has been termed natural cytotoxicity receptors (NCR) are represented by NKp46, NKp44 and NKp30. These receptors are strictly confined to NK cells, and their engagement induces a strong activation of NK-mediated cytolysis. A directcorrelation exists between the surface density of NCR and the ability of NK cells to kill various target cells. Importantly, mAb-mediated blocking ofthese receptors has been shown to suppress cytotoxicity against most NK-susceptible target cells. However, the process of NK-cell triggering during target cell lysis may also depend on the concerted action of NCR and other triggering receptors, such as NKG2D, or surface molecules, including 2B4 andNKp80, that appear to function as co-receptors rather than as true receptors. Notably, a dysfunction of 2B4 has been associated with a severe form ofimmunodeficiency termed X-linked lymphoproliferative disease. Future studies will clarify whether also the altered expression and/or function of other NK-triggering molecules may represent a. possible cause of immunological disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:17:22