Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasma serotonin response to carbohydrate-rich food in chronic schizophrenic patients: clozapine versus classic antipsychotic agents
Autore:
Vered, Y; Spivak, B; Nechmad, A; Schlapnikov, N; Graff, E; Feinberg, I; Gruper, D; Weiss, M; Kotler, M; Weizman, A; Mester, R;
Indirizzi:
Ness Ziona Mental Hlth Ctr, Res Unit, IL-74100 Ness Ziona, Israel Ness Ziona Mental Hlth Ctr Ness Ziona Israel IL-74100 Ness Ziona, Israel Beer Yaakov Mental Hlth Ctr, Beer Yaagov, Israel Beer Yaakov Mental Hlth Ctr Beer Yaagov Israel Ctr, Beer Yaagov, Israel Tel Aviv Sourasky Med Ctr, Lab Clin Biochem, Tel Aviv, Israel Tel Aviv Sourasky Med Ctr Tel Aviv Israel lin Biochem, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel Shalvata Mental Hlth Ctr, Hod Hasharon, Israel Shalvata Mental Hlth Ctr Hod Hasharon Israel Ctr, Hod Hasharon, Israel Felsenstein Med Res Ctr, Lab Biol Psychiat, Petah Tiqwa, Israel Felsenstein Med Res Ctr Petah Tiqwa Israel sychiat, Petah Tiqwa, Israel Ben Gurion Univ Negev, Fac Med, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Geha Psychiat Hosp, Rabin Med Ctr, Res Unit, Petah Tiqwa, Israel Geha Psychiat Hosp Petah Tiqwa Israel tr, Res Unit, Petah Tiqwa, Israel
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 5, volume: 16, anno: 2001,
pagine: 403 - 407
SICI:
0885-6222(200107)16:5<403:PSRTCF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEAL COMPOSITION; SCALE;
Keywords:
schizophrenia; clozapine; serotonin; carbohydrate-rich meal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Spivak, B Ness Ziona Mental Hlth Ctr, Res Unit, POB 1, IL-74100 Ness Ziona, Israel Ness Ziona Mental Hlth Ctr POB 1 Ness Ziona Israel IL-74100 ael
Citazione:
Y. Vered et al., "Plasma serotonin response to carbohydrate-rich food in chronic schizophrenic patients: clozapine versus classic antipsychotic agents", HUM PSYCHOP, 16(5), 2001, pp. 403-407

Abstract

Researchers have reported a stimulatory effect of carbohydrate-rich intakeon platelet-poor plasma (PPP) serotonin (5-HT) levels in healthy human subjects. Dietary manipulation may serve as a safer and less invasive means than pharmacologic challenge to provoke serotonergic responsivity in studies of schizophrenia. In the present study, we used the carbohydrate-rich meal test as an indicator of 5-HT activity in 12 patients with chronic schizophrenia maintained for at least 6 months on clozapine. PPP 5-HT levels were measured at baseline and at 1, 2 and 3 h after administration of the test. Findings were compared with those in schizophrenic patients treated with classic antipsychotic agents for the same duration. The maximal PPP 5-HT response was reached 120 min after meal administration in the clozapine-treated group and 60 min after in the classic antipsychotic-treated group (P < 0.05 vs baseline for both). The 5-HT level (as percentage of baseline) at 60 minwas significantly lower in the clozapine-treated group (P < 0.02), as wereindividual PPP 5-HT peak values (P < 0.05). The individual time to reach the peak response was similar in the two groups. Our results indicate that in patients with chronic schizophrenia 5-HT responsivity to the natural challenge of carbohydrate-rich meals is lower in those treated with clozapine than in those given classic antipsychotic agents. Values in both groups werelower than those in an appropriate historical comparative group of healthysubjects. We suggest that both clozapine and classic antipsychotic agents suppress serotonergic system sensitivity, but to a different degree. Copyright <(c)> 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:17:48