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Titolo:
Expression of clusterin in Crohn's disease of the terminal ileum
Autore:
Gassler, N; Autschbach, F; Heuschen, G; Witzgall, R; Otto, HF; Obermuller, N;
Indirizzi:
Univ Heidelberg, Inst Pathol, INF 220 221, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Heidelberg, Dept Surg, Heidelberg, Germany Univ Heidelberg Heidelberg Germany berg, Dept Surg, Heidelberg, Germany Univ Heidelberg, Inst Anat & Cell Biol 1, Heidelberg, Germany Univ Heidelberg Heidelberg Germany t & Cell Biol 1, Heidelberg, Germany Univ Heidelberg, Med Res Ctr Mannheim, Heidelberg, Germany Univ Heidelberg Heidelberg Germany es Ctr Mannheim, Heidelberg, Germany Univ Frankfurt, Med Clin 4, Div Nephrol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 phrol, D-6000 Frankfurt, Germany
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 755 - 762
SICI:
0213-3911(200107)16:3<755:EOCICD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL PERMEABILITY; EPITHELIAL-CELLS; MESSENGER-RNA; RELATIVES; RAT; DIFFERENTIATION; LOCALIZATION; CHAPERONE; PROTEINS; COLITIS;
Keywords:
apolipoprotein j; Crohn's disease; enterocytes; ileum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gassler, N Univ Heidelberg, Inst Pathol, INF 220 221, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 eidelberg, Germany
Citazione:
N. Gassler et al., "Expression of clusterin in Crohn's disease of the terminal ileum", HIST HISTOP, 16(3), 2001, pp. 755-762

Abstract

Crohn's disease (CD) is a chronic inflammatory intestinal disorder with disturbance and injury of the intestinal mucosal barrier, in which various proinflammatory molecules as well as molecules with antiinflammatory activityand cytoprotective function are found to be expressed. We investigated whether clusterin, a multifunctional cytoprotective protein, is upregulated inCrohn's disease, because augmented expression of clusterin is seen in manyorgans following various forms of tissue injury. Human actively and inactively inflamed ileal tissues from CD patients as well as normal intestinal specimens from control patients (normal ileum) were investigated by Western blot analysis, immunohistochemisty and in situ hybridization. As compared with controls, a strongly enhanced expression of clusterin was found in CD tissues, correlating with disease activity. Immunohistochemistry and in situhybridization analysis revealed foci of crypts almost completely lined by clusterin expressing enterocytes in CD, a feature that was never seen in controls. Such crypts appeared especially within the morphologically intact mucosa apart from erosive or ulcerative lesions. Besides epithelia, clusterin was also expressed by inflammatory mononuclear cells. Enhanced expressionof clusterin by crypt epithelia might reflect a cytoprotective function ofthe protein in order to prevent further injury of the intestinal mucosal barrier in CD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:23:32