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Titolo:
Protein phosphatase 2C alpha expression in normal human tissues: an immunohistochemical study
Autore:
Lifschitz-Mercer, B; Sheinin, Y; Ben-Meir, D; Bramante-Schreiber, L; Leider-Trejo, L; Karby, S; Smorodinsky, NI; Lavi, S;
Indirizzi:
Tel Aviv Univ, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel Tel AvivUniv Tel Aviv Israel IL-69978 mmunol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Inst Pathol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 Pathol, IL-64239 Tel Aviv, Israel
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 1, volume: 116, anno: 2001,
pagine: 31 - 39
SICI:
0948-6143(200107)116:1<31:PP2AEI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAROTID ACINAR-CELLS; MOLECULAR-CLONING; FISSION YEAST; 2C PP2C; KINASE; 2C-BETA; PHOSPHORYLATION; IDENTIFICATION; LOCALIZATION; PURIFICATION;
Keywords:
protein phosphatase 2C alpha; tissue distribution; human; histology; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lavi, S Tel Aviv Univ, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 IL-69978 Tel Aviv, Israel
Citazione:
B. Lifschitz-Mercer et al., "Protein phosphatase 2C alpha expression in normal human tissues: an immunohistochemical study", HISTOCHEM C, 116(1), 2001, pp. 31-39

Abstract

Protein phosphatase (PP2C alpha) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2C alpha and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2C alpha expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2C alpha expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2C alpha expression might contribute to secretory cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 05:32:24